Reduced-calorie orange juice beverage with plant sterols lowers C-reactive protein concentrations and improves the lipid profile in human volunteers
Language: 
English
Abstract: 

BACKGROUND: Dietary plant sterols effectively reduce LDL cholesterol when incorporated into fat matrices. We showed previously that supplementation with orange juice containing plant sterols (2 g/d) significantly reduced LDL cholesterol. Inflammation is pivotal in atherosclerosis. High-sensitivity C-reactive protein (hs-CRP), the prototypic marker of inflammation, is a cardiovascular disease risk marker; however, there is a paucity of data on the effect of plant sterols on CRP concentrations. OBJECTIVE: The aim of this study was to examine whether plant sterols affect CRP concentrations and the lipoprotein profile when incorporated into a reduced-calorie (50 calories/240 mL) orange juice beverage. DESIGN: Seventy-two healthy subjects were randomly assigned to receive a reduced-calorie orange juice beverage either without (Placebo Bev) or with (1 g/240 mL; Sterol Bev) plant sterols twice a day with meals for 8 wk. Fasting blood was obtained at baseline and after 8 wk of Placebo Bev or Sterol Bev supplementation. RESULTS: Sterol Bev supplementation significantly reduced total cholesterol (5%; P < 0.01) and LDL cholesterol (9.4%; P < 0.001) compared with both baseline and Placebo Bev (P < 0.05). HDL cholesterol increased significantly with Sterol Bev (P < 0.02). No significant changes in triacylglycerol, glucose, or liver function tests were observed with Sterol Bev. Sterol Bev supplementation resulted in no significant change in vitamin E and carotenoid concentrations. Sterol Bev supplementation resulted in a significant reduction of CRP concentrations compared with baseline and Placebo Bev (median reduction: 12%; P < 0.005). CONCLUSION: Supplementation with a reduced-calorie orange juice beverage containing plant sterols is effective in reducing CRP and LDL cholesterol and could be incorporated into the dietary portion of therapeutic lifestyle changes.

Author(s): 
Devaraj, Sridevi
Autret, Bryce C.
Jialal, Ishwarlal
Item Type: 
Journal Article
Publication Title: 
The American Journal of Clinical Nutrition
Journal Abbreviation: 
Am. J. Clin. Nutr.
Publication Date: 
Oct 2006
Publication Year: 
2006
Pages: 
756-761
Volume: 
84
Issue: 
4
ISSN: 
0002-9165
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 17023701

Turabian/Chicago Citation

Sridevi Devaraj, Bryce C. Autret and Ishwarlal Jialal. Oct 2006. "Reduced-calorie orange juice beverage with plant sterols lowers C-reactive protein concentrations and improves the lipid profile in human volunteers." The American Journal of Clinical Nutrition 84: 4: 756-761.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 0002-9165 | volume = 84 | pages = 756-761 | last = Devaraj | first = Sridevi | coauthors = Autret, Bryce C., Jialal, Ishwarlal | title = Reduced-calorie orange juice beverage with plant sterols lowers C-reactive protein concentrations and improves the lipid profile in human volunteers | journal = The American Journal of Clinical Nutrition | date = Oct 2006 | pmid = | pmc = }} </ref>