Regulation of longevity by the reproductive system
Language: 
English
Abstract: 

Pioneering work in model organisms reveals that the reproductive system is involved not only in propagation of the species but also regulates organismal metabolism and longevity. In C. elegans, prevention of germline stem cell proliferation results in a 60% extension of lifespan, termed gonadal longevity. Gonadal longevity relies on the transcriptional activities of steroid nuclear receptor DAF-12, the FOXO transcription factor homolog DAF-16, the FOXA transcription factor homolog PHA-4, and the HNF-4-like nuclear receptor NHR-80. These transcription factors work in an integrated transcriptional network to regulate fatty acid lipolysis, autophagy, stress resistance and other processes, which altogether enhance homeostasis and extend life. Because the reproductive system also regulates longevity in other species, studies in C. elegans may shed light on ancient mechanisms governing reproduction and survival.

Author(s): 
Antebi, Adam
Item Type: 
Journal Article
Publication Title: 
Experimental Gerontology
Journal Abbreviation: 
Exp. Gerontol.
Publication Date: 
2013-07
Publication Year: 
2013
Pages: 
596-602
Volume: 
48
Issue: 
7
ISSN: 
1873-6815
DOI: 
10.1016/j.exger.2012.09.009
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 23063987 PMCID: PMC3593982

Turabian/Chicago Citation

Adam Antebi. 2013-07. "Regulation of longevity by the reproductive system." Experimental Gerontology 48: 7: 596-602. 10.1016/j.exger.2012.09.009.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.exger.2012.09.009 | issn = 1873-6815 | volume = 48 | pages = 596-602 | last = Antebi | first = Adam | coauthors = | title = Regulation of longevity by the reproductive system | journal = Experimental Gerontology | date = 2013-07 | pmid = | pmc = }} </ref>