Rejuvenation of gene expression pattern of aged human skin by broadband light treatment: a pilot study
Language: 
English
Short Title: 
Rejuvenation of gene expression pattern of aged human skin by broadband light treatment
Abstract: 

Studies in model organisms suggest that aged cells can be functionally rejuvenated, but whether this concept applies to human skin is unclear. Here we apply 3'-end sequencing for expression quantification ("3-seq") to discover the gene expression program associated with human photoaging and intrinsic skin aging (collectively termed "skin aging"), and the impact of broadband light (BBL) treatment. We find that skin aging was associated with a significantly altered expression level of 2,265 coding and noncoding RNAs, of which 1,293 became "rejuvenated" after BBL treatment; i.e., they became more similar to their expression level in youthful skin. Rejuvenated genes (RGs) included several known key regulators of organismal longevity and their proximal long noncoding RNAs. Skin aging is not associated with systematic changes in 3'-end mRNA processing. Hence, BBL treatment can restore gene expression pattern of photoaged and intrinsically aged human skin to resemble young skin. In addition, our data reveal, to our knowledge, a previously unreported set of targets that may lead to new insights into the human skin aging process.

Author(s): 
Chang, Anne Lynn S.
Bitter, Patrick H.
Qu, Kun
Lin, Meihong
Rapicavoli, Nicole A.
Chang, Howard Y.
Item Type: 
Journal Article
Publication Title: 
The Journal of Investigative Dermatology
Journal Abbreviation: 
J. Invest. Dermatol.
Publication Date: 
2013-02
Publication Year: 
2013
Pages: 
394-402
Volume: 
133
Issue: 
2
ISSN: 
1523-1747
DOI: 
10.1038/jid.2012.287
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 22931923 PMCID: PMC3547222

Turabian/Chicago Citation

Anne Lynn S. Chang, Patrick H. Bitter, Kun Qu, Meihong Lin, Nicole A. Rapicavoli and Howard Y. Chang. 2013-02. "Rejuvenation of gene expression pattern of aged human skin by broadband light treatment: a pilot study." The Journal of Investigative Dermatology 133: 2: 394-402. 10.1038/jid.2012.287.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1038/jid.2012.287 | issn = 1523-1747 | volume = 133 | pages = 394-402 | last = Chang | first = Anne Lynn S. | coauthors = Bitter, Patrick H., Qu, Kun, Lin, Meihong, Rapicavoli, Nicole A., Chang, Howard Y. | title = Rejuvenation of gene expression pattern of aged human skin by broadband light treatment: a pilot study | journal = The Journal of Investigative Dermatology | date = 2013-02 | pmid = | pmc = }} </ref>