Relationship between serum isoflavone levels and disability-free survival among community-dwelling elderly individuals: nested case-control study of the Tsurugaya project
Language: 
English
Short Title: 
Relationship between serum isoflavone levels and disability-free survival among community-dwelling elderly individuals
Abstract: 

BACKGROUND: The longer healthy life expectancy observed in Japan may be partly attributed to the Japanese diet. The researchers sought to examine whether serum isoflavone levels are associated with disability and death. METHODS: The researchers used a nested case-control study to compare serum isoflavones (daidzein, genistein, glycitein, and equol) levels between 165 participants that died or were certificated as disabled (cases) and 177 controls. Disability was defined by certification of long-term care insurance. Conditional logistic regression models were used to calculate the risk of isoflavones for the composite outcome. RESULTS: The proportion of cases was lower in the group with the highest levels of equol (34/91, 37%) compared with equol nonproducers (84/161, 52%). The risk of disability or death among equol producers remained reduced after adjusting for age and sex (odds ratio: 0.55, 95% confidence interval: 0.33-0.93). In a multivariate model, this risk was also unchanged (odds ratio: 0.51, 95% confidence interval: 0.27-0.96). There were no significant associations between daidzein, genistein, and glycitein with the composite endpoint. CONCLUSIONS: Higher serum equol levels, but not any other isoflavones, were inversely associated with the composite endpoint of disability and death. Although it cannot be concluded that equol per se has preventive effects on disability or death, higher equol levels appear associated with better health.

Author(s): 
Hozawa, Atsushi
Sugawara, Yumi
Tomata, Yasutake
Kakizaki, Masako
Tsuboya, Toru
Ohmori-Matsuda, Kaori
Nakaya, Naoki
Kuriyama, Shinichi
Fukao, Akira
Tsuji, Ichiro
Item Type: 
Journal Article
Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Journal Abbreviation: 
J. Gerontol. A Biol. Sci. Med. Sci.
Publication Date: 
2013-04
Publication Year: 
2013
Pages: 
465-472
Volume: 
68
Issue: 
4
ISSN: 
1758-535X
DOI: 
10.1093/gerona/gls198
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 23051976

Turabian/Chicago Citation

Atsushi Hozawa, Yumi Sugawara, Yasutake Tomata, Masako Kakizaki, Toru Tsuboya, Kaori Ohmori-Matsuda, Naoki Nakaya, Shinichi Kuriyama, Akira Fukao and Ichiro Tsuji. 2013-04. "Relationship between serum isoflavone levels and disability-free survival among community-dwelling elderly individuals: nested case-control study of the Tsurugaya project." The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 68: 4: 465-472. 10.1093/gerona/gls198.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1093/gerona/gls198 | issn = 1758-535X | volume = 68 | pages = 465-472 | last = Hozawa | first = Atsushi | coauthors = Sugawara, Yumi, Tomata, Yasutake, Kakizaki, Masako, Tsuboya, Toru, Ohmori-Matsuda, Kaori, Nakaya, Naoki, Kuriyama, Shinichi, Fukao, Akira, Tsuji, Ichiro | title = Relationship between serum isoflavone levels and disability-free survival among community-dwelling elderly individuals: nested case-control study of the Tsurugaya project | journal = The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences | date = 2013-04 | pmid = | pmc = }} </ref>