Relationship of bispectral index to minimum alveolar concentration during isoflurane, sevoflurane or desflurane anaesthesia
Language: 
English
Abstract: 

OBJECTIVE: To determine bispectral index (BIS) values produced by equipotent concentrations of commonly used volatile anaesthetics. METHODS: Female patients undergoing thyroidectomy were randomly assigned to receive isoflurane, sevoflurane or desflurane anaesthesia. After induction, anaesthesia was maintained by the volatile agent at 1 minimum alveolar concentration and supplemented with remifentanil infusion. BIS values were recorded during 1?h surgical anaesthesia after a 15?min equilibrium phase. RESULTS: Time-averaged BIS value during the study period was significantly lower in the desflurane group (n?=?29) than the sevoflurane group (n?=?27) (37.0?±?4.9 vs 41.5?±?5.9). Duration of deep hypnosis (BIS?<?40) was significantly longer in the desflurane group than the sevoflurane group (40.2?±?20.7 vs 24.3?±?22.5?min). There were no significant differences in any parameter between the isoflurane group (n?=?27) and any other group. CONCLUSIONS: Desflurane produces a greater hypnotic effect than sevoflurane during equipotent anaesthesia. Management of volatile anaesthesia using predetermined minimum alveolar concentration targets can lead to an unnecessarily long duration of deep hypnosis.

Author(s): 
Kim, Jin-Kyoung
Kim, Duk-Kyung
Lee, Myeong-Jin
Item Type: 
Journal Article
Publication Title: 
The Journal of International Medical Research
Journal Abbreviation: 
J. Int. Med. Res.
Publication Date: 
2/14/2015
Publication Year: 
2014
Pages: 
130-137
Volume: 
42
Issue: 
1
ISSN: 
1473-2300
DOI: 
10.1177/0300060513505525
Library Catalog: 
PubMed
Extra: 
PMID: 24366495

Turabian/Chicago Citation

Jin-Kyoung Kim, Duk-Kyung Kim and Myeong-Jin Lee. 2/14/2015. "Relationship of bispectral index to minimum alveolar concentration during isoflurane, sevoflurane or desflurane anaesthesia." The Journal of International Medical Research 42: 1: 130-137. 10.1177/0300060513505525.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1177/0300060513505525 | issn = 1473-2300 | volume = 42 | pages = 130-137 | last = Kim | first = Jin-Kyoung | coauthors = Kim, Duk-Kyung, Lee, Myeong-Jin | title = Relationship of bispectral index to minimum alveolar concentration during isoflurane, sevoflurane or desflurane anaesthesia | journal = The Journal of International Medical Research | date = 2/14/2015 | pmid = | pmc = }} </ref>