Respiratory uncoupling in skeletal muscle delays death and diminishes age-related disease
Language: 
English
Abstract: 

Age-related disease, not aging per se, causes most morbidity in older humans. Here we report that skeletal muscle respiratory uncoupling due to UCP1 expression diminishes age-related disease in three mouse models. In a longevity study, median survival was increased in UCP mice (animals with skeletal muscle-specific UCP1 expression), and lymphoma was detected less frequently in UCP female mice. In apoE null mice, a vascular disease model, diet-induced atherosclerosis was decreased in UCP animals. In agouti yellow mice, a genetic obesity model, diabetes and hypertension were reversed by induction of UCP1 in skeletal muscle. Uncoupled mice had decreased adiposity, increased temperature and metabolic rate, elevated muscle SIRT and AMP kinase, and serum characterized by increased adiponectin and decreased IGF-1 and fibrinogen. Accelerating metabolism in skeletal muscle does not appear to impact aging but may delay age-related disease.

Author(s): 
Gates, Allison C.
Bernal-Mizrachi, Carlos
Chinault, Sharon L.
Feng, Chu
Schneider, Jochen G.
Coleman, Trey
Malone, James P.
Townsend, R. Reid
Chakravarthy, Manu V.
Semenkovich, Clay F.
Item Type: 
Journal Article
Publication Title: 
Cell Metabolism
Journal Abbreviation: 
Cell Metab.
Publication Date: 
2007-12
Publication Year: 
2007
Pages: 
497-505
Volume: 
6
Issue: 
6
ISSN: 
1550-4131
DOI: 
10.1016/j.cmet.2007.10.010
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 18054318

Turabian/Chicago Citation

Allison C. Gates, Carlos Bernal-Mizrachi, Sharon L. Chinault, Chu Feng, Jochen G. Schneider, Trey Coleman, James P. Malone, R. Reid Townsend, Manu V. Chakravarthy and Clay F. Semenkovich. 2007-12. "Respiratory uncoupling in skeletal muscle delays death and diminishes age-related disease." Cell Metabolism 6: 6: 497-505. 10.1016/j.cmet.2007.10.010.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.cmet.2007.10.010 | issn = 1550-4131 | volume = 6 | pages = 497-505 | last = Gates | first = Allison C. | coauthors = Bernal-Mizrachi, Carlos, Chinault, Sharon L., Feng, Chu, Schneider, Jochen G., Coleman, Trey, Malone, James P., Townsend, R. Reid, Chakravarthy, Manu V., Semenkovich, Clay F. | title = Respiratory uncoupling in skeletal muscle delays death and diminishes age-related disease | journal = Cell Metabolism | date = 2007-12 | pmid = | pmc = }} </ref>