Response of intracerebral human glioblastoma xenografts to multifraction radiation exposures
Language: 
English
Abstract: 

PURPOSE: We investigated the effects of fractionated radiation treatments on the life spans of athymic rats bearing intracerebral brain tumors. METHODS AND MATERIALS: U-251 MG or U-87 MG human glioblastoma cells were implanted into the brains of athymic rats, and the resulting tumors were irradiated once daily with various doses of ionizing radiation for 5 consecutive days or for 10 days with a 2-day break after Day 5. RESULTS: Five daily doses of 1 and 1.5 Gy, and 10 doses of 0.75 and 1 Gy, cured some U-251 MG tumors. However, five daily doses of 0.5 Gy increased the survival time of animals bearing U-251 MG tumors 5 days without curing any animals of their tumors. Ten doses of 0.3 Gy given over 2 weeks extended the lifespan of the host animals 9 days without curing any animals. For U-87 MG tumors, 5 daily doses of 3 Gy produced an increased lifespan of 8 days without curing any animals, and 10 doses of 1 Gy prolonged lifespan 5.5 days without curing any animals. The differences in extension of life span between the 5- and 10-fraction protocols were minor for either tumor type. CONCLUSION: The finding that the U-251 MG tumors are more sensitive than U-87 MG tumors, despite the fact that U-251 MG tumors contain many more hypoxic cells than U-87 MG tumors, suggests the intrinsic cellular radiosensitivities of these cell lines are more important than hypoxia in determining their in vivo radiosensitivities.

Author(s): 
Ozawa, Tomoko
Faddegon, Bruce A.
Hu, Lily J.
Bollen, Andrew W.
Lamborn, Kathleen R.
Deen, Dennis F.
Item Type: 
Journal Article
Publication Title: 
International Journal of Radiation Oncology, Biology, Physics
Journal Abbreviation: 
Int. J. Radiat. Oncol. Biol. Phys.
Publication Date: 
9/1/2006
Publication Year: 
2006
Pages: 
263-270
Volume: 
66
Issue: 
1
ISSN: 
0360-3016
DOI: 
10.1016/j.ijrobp.2006.05.010
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 16904526

Turabian/Chicago Citation

Tomoko Ozawa, Bruce A. Faddegon, Lily J. Hu, Andrew W. Bollen, Kathleen R. Lamborn and Dennis F. Deen. 9/1/2006. "Response of intracerebral human glioblastoma xenografts to multifraction radiation exposures." International Journal of Radiation Oncology, Biology, Physics 66: 1: 263-270. 10.1016/j.ijrobp.2006.05.010.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.ijrobp.2006.05.010 | issn = 0360-3016 | volume = 66 | pages = 263-270 | last = Ozawa | first = Tomoko | coauthors = Faddegon, Bruce A., Hu, Lily J., Bollen, Andrew W., Lamborn, Kathleen R., Deen, Dennis F. | title = Response of intracerebral human glioblastoma xenografts to multifraction radiation exposures | journal = International Journal of Radiation Oncology, Biology, Physics | date = 9/1/2006 | pmid = | pmc = }} </ref>