Resveratrol, sirtuins, and the promise of a DR mimetic
Language: 
English
Abstract: 

Dietary restriction (DR) delays or prevents age-related diseases and extends lifespan in species ranging from yeast to primates. Although the applicability of this regimen to humans remains uncertain, a proportional response would add more healthy years to the average life than even a cure for cancer or heart disease. Because it is unlikely that many would be willing or able to maintain a DR lifestyle, there has been intense interest in mimicking its beneficial effects on health, and potentially longevity, with drugs. To date, such efforts have been hindered primarily by our lack of mechanistic understanding of how DR works. Sirtuins, NAD(+)-dependent deacetylases and ADP-ribosyltransferases that influence lifespan in lower organisms, have been proposed to be key mediators of DR, and based on this model, the sirtuin activator resveratrol has been proposed as a candidate DR mimetic. Indeed, resveratrol extends lifespan in yeast, worms, flies, and a short-lived species of fish. In rodents, resveratrol improves health, and prevents the early mortality associated with obesity, but its precise mechanism of action remains a subject of debate, and extension of normal lifespan has not been observed. This review summarizes recent work on resveratrol, sirtuins, and their potential to mimic beneficial effects of DR.

Author(s): 
Baur, Joseph A.
Item Type: 
Journal Article
Publication Title: 
Mechanisms of Ageing and Development
Journal Abbreviation: 
Mech. Ageing Dev.
Publication Date: 
2010-04
Publication Year: 
2010
Pages: 
261-269
Volume: 
131
Issue: 
4
ISSN: 
1872-6216
DOI: 
10.1016/j.mad.2010.02.007
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 20219519 PMCID: PMC2862768

Turabian/Chicago Citation

Joseph A. Baur. 2010-04. "Resveratrol, sirtuins, and the promise of a DR mimetic." Mechanisms of Ageing and Development 131: 4: 261-269. 10.1016/j.mad.2010.02.007.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.mad.2010.02.007 | issn = 1872-6216 | volume = 131 | pages = 261-269 | last = Baur | first = Joseph A. | coauthors = | title = Resveratrol, sirtuins, and the promise of a DR mimetic | journal = Mechanisms of Ageing and Development | date = 2010-04 | pmid = | pmc = }} </ref>