A retinoic acid-dependent checkpoint in the development of CD4+ T cell-mediated immunity
Language: 
English
Abstract: 

It is known that vitamin A and its metabolite, retinoic acid (RA), are essential for host defense. However, the mechanisms for how RA controls inflammation are incompletely understood. The findings presented in this study show that RA signaling occurs concurrent with the development of inflammation. In models of vaccination and allogeneic graft rejection, whole body imaging reveals that RA signaling is temporally and spatially restricted to the site of inflammation. Conditional ablation of RA signaling in T cells significantly interferes with CD4(+) T cell effector function, migration, and polarity. These findings provide a new perspective of the role of RA as a mediator directly controlling CD4(+) T cell differentiation and immunity.

Author(s): 
Pino-Lagos, Karina
Guo, Yanxia
Brown, Chrysothemis
Alexander, Matthew P.
Elgueta, Raúl
Bennett, Kathryn A.
De Vries, Victor
Nowak, Elizabeth
Blomhoff, Rune
Sockanathan, Shanthini
Chandraratna, Roshantha A.
Dmitrovsky, Ethan
Noelle, Randolph J.
Item Type: 
Journal Article
Publication Title: 
The Journal of Experimental Medicine
Journal Abbreviation: 
J. Exp. Med.
Publication Date: 
Aug 29, 2011
Publication Year: 
2011
Pages: 
1767-1775
Volume: 
208
Issue: 
9
ISSN: 
1540-9538
DOI: 
10.1084/jem.20102358
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 21859847 PMCID: PMC3171100

Turabian/Chicago Citation

Karina Pino-Lagos, Yanxia Guo, Chrysothemis Brown, Matthew P. Alexander, Raúl Elgueta, Kathryn A. Bennett, Victor De Vries, Elizabeth Nowak, Rune Blomhoff, Shanthini Sockanathan, Roshantha A. Chandraratna, Ethan Dmitrovsky and Randolph J. Noelle. Aug 29, 2011. "A retinoic acid-dependent checkpoint in the development of CD4+ T cell-mediated immunity." The Journal of Experimental Medicine 208: 9: 1767-1775. 10.1084/jem.20102358.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1084/jem.20102358 | issn = 1540-9538 | volume = 208 | pages = 1767-1775 | last = Pino-Lagos | first = Karina | coauthors = Guo, Yanxia, Brown, Chrysothemis, Alexander, Matthew P., Elgueta, Raúl, Bennett, Kathryn A., De Vries, Victor, Nowak, Elizabeth, Blomhoff, Rune, Sockanathan, Shanthini, Chandraratna, Roshantha A., Dmitrovsky, Ethan, Noelle, Randolph J. | title = A retinoic acid-dependent checkpoint in the development of CD4+ T cell-mediated immunity | journal = The Journal of Experimental Medicine | date = Aug 29, 2011 | pmid = | pmc = }} </ref>