Rostral anterior cingulate cortex theta current density and response to antidepressants and placebo in major depression
Language: 
English
Abstract: 

OBJECTIVE: To assess whether pretreatment theta current density in the rostral anterior cingulate (rACC) and medial orbitofrontal cortex (mOFC) differentiates responders from non-responders to antidepressant medication or placebo in a double-blinded study. METHODS: Pretreatment EEGs were collected from 72 subjects with Major Depressive Disorder (MDD) who participated in one of three placebo-controlled trials. Subjects were randomized to receive treatment with fluoxetine, venlafaxine, or placebo. Low-resolution brain electromagnetic tomography (LORETA) was used to assess theta current density in the rACC and mOFC. RESULTS: Medication responders showed elevated rACC and mOFC theta current density compared to medication non-responders (rACC: p=0.042; mOFC: p=0.039). There was no significant difference in either brain region between placebo responders and placebo non-responders. CONCLUSIONS: Theta current density in the rACC and mOFC may be useful as a biomarker for prediction of response to antidepressant medication. SIGNIFICANCE: This is the first double-blinded treatment study to examine pretreatment rACC and mOFC theta current density in relation to antidepressant response and placebo response. Results support the potential clinical utility of this approach for predicting clinical outcome to antidepressant treatments in MDD.

Author(s): 
Korb, Alexander S.
Hunter, Aimee M.
Cook, Ian A.
Leuchter, Andrew F.
Item Type: 
Journal Article
Publication Title: 
Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
Journal Abbreviation: 
Clin Neurophysiol
Publication Date: 
Jul 2009
Publication Year: 
2009
Pages: 
1313-1319
Volume: 
120
Issue: 
7
ISSN: 
1872-8952
DOI: 
10.1016/j.clinph.2009.05.008
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 19539524 PMCID: PMC2710394

Turabian/Chicago Citation

Alexander S. Korb, Aimee M. Hunter, Ian A. Cook and Andrew F. Leuchter. Jul 2009. "Rostral anterior cingulate cortex theta current density and response to antidepressants and placebo in major depression." Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology 120: 7: 1313-1319. 10.1016/j.clinph.2009.05.008.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.clinph.2009.05.008 | issn = 1872-8952 | volume = 120 | pages = 1313-1319 | last = Korb | first = Alexander S. | coauthors = Hunter, Aimee M., Cook, Ian A., Leuchter, Andrew F. | title = Rostral anterior cingulate cortex theta current density and response to antidepressants and placebo in major depression | journal = Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology | date = Jul 2009 | pmid = | pmc = }} </ref>