Scientific evidence on the role of Ayurvedic herbals on bioavailability of drugs
Language: 
English
Abstract: 

Experiments were conducted to evaluate the scientific basis of the use of the trikatu group of acrids (long pepper, black pepper and ginger) in the large number of prescriptions in Ayurveda. [3H] vasicine and [3H] sparteine were taken as test drugs. Piper longum (long pepper) increased the blood levels of vasicine by nearly 233%. Under the influence of piperine, the active principle of Piper species, sparteine blood levels increased more than 100%. The results suggest that these acrids have the capacity to increase the bioavailability of certain drugs. It appears that the trikatu group of drugs increase bioavailability either by promoting rapid absorption from the gastrointestinal tract, or by protecting the drug from being metabolised/oxidised in its first passage through the liver after being absorbed, or by a combination of these two mechanisms.

Author(s): 
Atal, C. K.
Zutshi, U.
Rao, P. G.
Item Type: 
Journal Article
Publication Title: 
Journal of Ethnopharmacology
Journal Abbreviation: 
J Ethnopharmacol
Publication Date: 
Sep 1981
Publication Year: 
1981
Pages: 
229-232
Volume: 
4
Issue: 
2
ISSN: 
0378-8741
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 7311598

Turabian/Chicago Citation

C. K. Atal, U. Zutshi and P. G. Rao. Sep 1981. "Scientific evidence on the role of Ayurvedic herbals on bioavailability of drugs." Journal of Ethnopharmacology 4: 2: 229-232.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 0378-8741 | volume = 4 | pages = 229-232 | last = Atal | first = C. K. | coauthors = Zutshi, U., Rao, P. G. | title = Scientific evidence on the role of Ayurvedic herbals on bioavailability of drugs | journal = Journal of Ethnopharmacology | date = Sep 1981 | pmid = | pmc = }} </ref>