Search Articles

Publication Title: 
Neural Regeneration Research

Previous studies have shown that somatic sensation by acupuncture and visceral nociceptive stimulation can converge in the nucleus tractus solitarii where neurons integrate signals impacting on the function of organs. To explore the role of the nucleus tractus solitarii in the protective mechanism of pre-moxibustion on gastric mucosa, nucleus tractus solitarii were damaged in rats and pre-moxibustion treatment at the Zusanli (ST36) point followed. The gastric mucosa was then damaged by the anhydrous ethanol lavage method.

Author(s): 
Peng, Liang
Liu, Mi
Chang, Xiaorong
Yang, Zhou
Yi, Shouxiang
Yan, Jie
Peng, Yan
Publication Title: 
Neural Regeneration Research

Acupuncture at Baihui (GV20) and Dazhui (GV14) reduces neuronal loss and attenuates ultrastructural damage in cerebral ischemic rats. However, whether acupuncture can treat addiction and prevent readdiction through changes to brain cell ultrastructure remains unknown. In this study, cell apoptosis was observed in the hippocampus and frontal lobe of heroin readdicted rats by electron microscopy. Immunohistochemical staining displayed a reduction in Bcl-2 expression and an increase in Bax expression in the hippocampus and frontal lobe.

Author(s): 
Hou, Xiaorong
Zhang, Rongjun
Lv, Hang
Cai, Xinghui
Xie, Guangchuan
Song, Xiaoge
Publication Title: 
Neural Regeneration Research
Author(s): 
Wiwanitkit, Viroj
Publication Title: 
Neural Regeneration Research

Our previous findings have demonstrated that acupuncture at the Taixi (KI3) acupoint in healthy youths can activate neurons in cognitive-related cerebral cortex. Here, we investigated whether acupuncture at this acupoint in elderly patients with mild cognitive impairment can also activate neurons in these regions. Resting state and task-related functional magnetic resonance imaging showed that the pinprick senstation of acupuncture at the Taixi acupoint differed significantly between elderly patients with mild cognitive impairment and healthy elderly controls.

Author(s): 
Chen, Shangjie
Xu, Maosheng
Li, Hong
Liang, Jiuping
Yin, Liang
Liu, Xia
Jia, Xinyan
Zhu, Fen
Wang, Dan
Shi, Xuemin
Zhao, Lihua
Publication Title: 
Neural Regeneration Research

Mesenchymal stem cell transplantation is a novel means of treating cerebral ischemia/reperfusion, and can promote angiogenesis and neurological functional recovery. Acupuncture at Conception and Governor vessels also has positive effects as a treatment for cerebral ischemia/reperfusion. Therefore, we hypothesized that electro-acupuncture at Conception and Governor vessels plus mesenchymal stem cell transplantation may have better therapeutic effects on the promotion of angiogenesis and recovery of neurological function than either treatment alone.

Author(s): 
Yu, Haibo
Chen, Pengdian
Yang, Zhuoxin
Luo, Wenshu
Pi, Min
Wu, Yonggang
Wang, Ling
Publication Title: 
Neural Regeneration Research

Preliminary basic research and clinical findings have demonstrated that electroacupuncture therapy exhibits positive effects in ameliorating depression. However, most studies of the underlying mechanism are at the single gene level; there are few reports regarding the mechanism at the whole-genome level. Using a rat genomic gene-chip, we profiled hippocampal gene expression changes in rats after electroacupuncture therapy. Electroacupuncture therapy alleviated depression-related manifestations in the model rats.

Author(s): 
Duan, Dongmei
Yang, Xiuyan
Ya, Tu
Chen, Liping
Publication Title: 
Neural Regeneration Research

Hemiplegia caused by stroke indicates dysfunction of the network between the brain and limbs, namely collateral shock in the brain. Contralateral needling is the insertion of needles into acupoints on the relative healthy side of the body to treat diseases such as apoplexy. However, there is little well-designed and controlled clinical evidence for this practice. This study investigated whether contralateral needling could treat hemiplegia after acute ischemic stroke in 106 randomly selected patients with acute ischemic stroke.

Author(s): 
Gao, Huanmin
Li, Xugang
Gao, Xia
Ma, Benxu
Publication Title: 
Neural Regeneration Research

The Alzheimer's disease model in Wistar rats was established by injection of amyloid β-peptide (Aβ1-42) into the hippocampal CA1 region. Rats were treated with suspended moxibustion on Baihui (GV20) and Shenshu (BL23) acupoints. Prior to and post Aβ1-42 exposure. Results showed no evidence of apoptosis in hippocampal neurons, a significantly reduced apoptosis rate of neurons and improved learning and memory abilities were observed in the Alzheimer's disease model.

Author(s): 
Du, Yanjun
Liu, Ruolan
Sun, Guojie
Meng, Peiyan
Song, Jie
Publication Title: 
Neural Regeneration Research

Shaoyang acupoints are the most frequently used in migraine treatment. However, the central analgesic mechanism remains poorly understood. Studies have demonstrated that single stimulus of the verum acupuncture in healthy subjects can induce significant connectivity or activity changes in pain-related central networks compared with sham acupuncture. However, these findings are not indicative of the central analgesic mechanism of acupuncture at Shaoyang acupoints.

Author(s): 
Lan, Lei
Gao, Yujie
Zeng, Fang
Qin, Wei
Dong, Mingkai
Liu, Mailan
Guo, Taipin
Liang, Fanrong
Publication Title: 
Neural Regeneration Research

The individual difference and non-repeatability in acupuncture have not only restricted the development of acupuncture, but have also affected the specificity of acupoints. The present study used instruments to control needle depth, lifting and thrusting frequency, and the duration of acupuncture. Effects of the quantified acupuncture were observed at Neiguan (PC6) with different stimulation parameters. A frequency of 1, 2, or 3 Hz and duration of 5, 60, or 180 seconds were used to observe cerebral blood flow and ratio of infarct volume recovery.

Author(s): 
Zhang, Yanan
Yang, Sha
Fan, Xiaonong
Wang, Shu
He, Nina
Li, Lingxin
Luo, Ding
Shi, Xuemin

Pages