Serotonin 5-HT2A receptor gene variants influence antidepressant response to repeated total sleep deprivation in bipolar depression
Language: 
English
Abstract: 

5-HT2A receptor density in prefrontal cortex was associated with depression and suicide. 5-HT2A receptor gene polymorphism rs6313 was associated with 5-HT2A receptor binding potential, with the ability of individuals to use environmental support in order to prevent depression, and with sleep improvement after antidepressant treatment with mirtazapine. Studies on response to antidepressant drugs gave inconsistent results. Here we studied the effect of rs6313 on response to repeated total sleep deprivation (TSD) in 80 bipolar depressed inpatients treated with three consecutive TSD cycles (each one made of 36 h awake followed by a night of undisturbed sleep). All genotype groups showed comparable acute effects of the first TSD, but patients homozygotes for the T variant had better perceived and observed benefits from treatment than carriers of the C allele. These effects became significant after the first recovery night and during the following days, leading to a 36% higher final response rate (Hamilton depression rating<8). The higher density of postsynaptic excitatory 5-HT2A receptors in T/T homozygotes could have led to higher behavioural effects of increased 5-HT neurotransmission due to repeated TSD. Other possible mechanisms involve allostatic/homeostatic adaptation to sleep loss, and a different effect of the allele variants on epigenetic influences. Results confirm the interest for individual gene variants of the serotonin pathway in shaping clinical characteristics of depression and antidepressant response.

Author(s): 
Benedetti, Francesco
Barbini, Barbara
Bernasconi, Alessandro
Fulgosi, Mara Cigala
Colombo, Cristina
Dallaspezia, Sara
Gavinelli, Chiara
Marino, Elena
Pirovano, Adele
Radaelli, Daniele
Smeraldi, Enrico
Item Type: 
Journal Article
Publication Title: 
Progress in Neuro-Psychopharmacology & Biological Psychiatry
Journal Abbreviation: 
Prog. Neuropsychopharmacol. Biol. Psychiatry
Publication Date: 
12/12/2008
Publication Year: 
2008
Pages: 
1863-1866
Volume: 
32
Issue: 
8
ISSN: 
0278-5846
DOI: 
10.1016/j.pnpbp.2008.08.017
Library Catalog: 
PubMed
Extra: 
PMID: 18801406

Turabian/Chicago Citation

Francesco Benedetti, Barbara Barbini, Alessandro Bernasconi, Mara Cigala Fulgosi, Cristina Colombo, Sara Dallaspezia, Chiara Gavinelli, Elena Marino, Adele Pirovano, Daniele Radaelli and Enrico Smeraldi. 12/12/2008. "Serotonin 5-HT2A receptor gene variants influence antidepressant response to repeated total sleep deprivation in bipolar depression." Progress in Neuro-Psychopharmacology & Biological Psychiatry 32: 8: 1863-1866. 10.1016/j.pnpbp.2008.08.017.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.pnpbp.2008.08.017 | issn = 0278-5846 | volume = 32 | pages = 1863-1866 | last = Benedetti | first = Francesco | coauthors = Barbini, Barbara, Bernasconi, Alessandro, Fulgosi, Mara Cigala, Colombo, Cristina, Dallaspezia, Sara, Gavinelli, Chiara, Marino, Elena, Pirovano, Adele, Radaelli, Daniele, Smeraldi, Enrico | title = Serotonin 5-HT2A receptor gene variants influence antidepressant response to repeated total sleep deprivation in bipolar depression | journal = Progress in Neuro-Psychopharmacology & Biological Psychiatry | date = 12/12/2008 | pmid = | pmc = }} </ref>