Serotype-specific host responses in rhesus macaques after primary dengue challenge
Language: 
English
Abstract: 

Dengue virus (DENV) is considered to be the most important arthropod-borne viral disease and causes more than 100 million human infections annually. To further characterize primary DENV infection in vivo, rhesus macaques were infected with DENV-1, DENV-2, DENV-3, or DENV-4 and clinical parameters, as well as specificity and longevity of serologic responses, were assessed. Overt clinical symptoms were not present after infection. However, abnormalities in blood biochemical parameters consistent with heart, kidney, and liver damage were observed, and changes in plasma fibrinogen, D-dimers, and protein C indicated systemic activation of the blood coagulation pathway. Significant homotypic and heterotypic serum immunoglobulins were present in all animals, and IgG persisted for at least 390 days. Serum neutralizing antibody responses were highly serotype specific by day 120. However, some heterotypic neutralizing activity was noted in infected animals. Identification of serotype-specific host responses may help elucidate mechanisms that mediate severe DENV disease after reinfection.

Author(s): 
Hickey, Andrew C.
Koster, Jacob A.
Thalmann, Claudia M.
Hardcastle, Kathy
Tio, Phaik-Hooi
Cardosa, Mary J.
Bossart, Katharine N.
Item Type: 
Journal Article
Publication Title: 
The American Journal of Tropical Medicine and Hygiene
Journal Abbreviation: 
Am. J. Trop. Med. Hyg.
Publication Date: 
2013-12
Publication Year: 
2013
Pages: 
1043-1057
Volume: 
89
Issue: 
6
ISSN: 
1476-1645
DOI: 
10.4269/ajtmh.13-0145
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 24062475 PMCID: PMC3854881

Turabian/Chicago Citation

Andrew C. Hickey, Jacob A. Koster, Claudia M. Thalmann, Kathy Hardcastle, Phaik-Hooi Tio, Mary J. Cardosa and Katharine N. Bossart. 2013-12. "Serotype-specific host responses in rhesus macaques after primary dengue challenge." The American Journal of Tropical Medicine and Hygiene 89: 6: 1043-1057. 10.4269/ajtmh.13-0145.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.4269/ajtmh.13-0145 | issn = 1476-1645 | volume = 89 | pages = 1043-1057 | last = Hickey | first = Andrew C. | coauthors = Koster, Jacob A., Thalmann, Claudia M., Hardcastle, Kathy, Tio, Phaik-Hooi, Cardosa, Mary J., Bossart, Katharine N. | title = Serotype-specific host responses in rhesus macaques after primary dengue challenge | journal = The American Journal of Tropical Medicine and Hygiene | date = 2013-12 | pmid = | pmc = }} </ref>