Serum cystatin C is an easy to obtain biomarker for the onset of renal impairment in heart transplant recipients
Language: 
English
Abstract: 

OBJECTIVE: With the increasing longevity of heart transplant recipients, the long-term effects of cyclosporine on renal function have become more evident. Highly sensitive, early, and effective monitoring of posttransplant renal function is still being researched. This study aimed to evaluate the prognostic value of cystatin C for patients after heart transplantation. METHODS: Seventy-three long-term recipients of a heart transplant more than 5 years before the study start were included in the analysis with a follow-up of 4 years. Serum creatinine, renal glomerular filtration rate calculated by the Modification of Diet in Renal Disease formula, and serum cystatin C levels were collected, and risk factors for renal dysfunction were assessed. Statistical analysis was performed for all patients. RESULTS: Univariate analysis showed a prognostic impact of antihypertensive medication and onset of diabetes (P < .001) on renal failure after transplantation. Multivariate analysis yielded cystatin C measured at the study start as a superior prognostic parameter for all time points (area under the receiver operating characteristic 12 months: 0.963; 24 months: 0.910; 48 months: 0.949) compared with the conventionally used creatinine levels. CONCLUSIONS: Our results showed an enormous potential of serum cystatin C as an early prognostic and easy to obtain biomarker for renal dysfunction after heart transplantation.

Author(s): 
Kniepeiss, Daniela
Wagner, Doris
Wirnsberger, Gerhard
Roller, Regina E.
Wasler, Andr‰
Iberer, Florian
Tscheliessnigg, Karl-Heinz
Item Type: 
Journal Article
Publication Title: 
The Journal of Thoracic and Cardiovascular Surgery
Journal Abbreviation: 
J. Thorac. Cardiovasc. Surg.
Publication Date: 
2010-09
Publication Year: 
2010
Pages: 
688-693
Volume: 
140
Issue: 
3
ISSN: 
1097-685X
DOI: 
10.1016/j.jtcvs.2010.03.031
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 20447660

Turabian/Chicago Citation

Daniela Kniepeiss, Doris Wagner, Gerhard Wirnsberger, Regina E. Roller, Andr‰ Wasler, Florian Iberer and Karl-Heinz Tscheliessnigg. 2010-09. "Serum cystatin C is an easy to obtain biomarker for the onset of renal impairment in heart transplant recipients." The Journal of Thoracic and Cardiovascular Surgery 140: 3: 688-693. 10.1016/j.jtcvs.2010.03.031.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.jtcvs.2010.03.031 | issn = 1097-685X | volume = 140 | pages = 688-693 | last = Kniepeiss | first = Daniela | coauthors = Wagner, Doris, Wirnsberger, Gerhard, Roller, Regina E., Wasler, Andr‰, Iberer, Florian, Tscheliessnigg, Karl-Heinz | title = Serum cystatin C is an easy to obtain biomarker for the onset of renal impairment in heart transplant recipients | journal = The Journal of Thoracic and Cardiovascular Surgery | date = 2010-09 | pmid = | pmc = }} </ref>