SIRT1 promotes tumorigenesis of hepatocellular carcinoma through PI3K/PTEN/AKT signaling
Language: 
English
Abstract: 

SIRT1 is the human orthologue of SIR2, a conserved NAD-dependent protein deacetylase that regulates longevity in yeast and in Caenorhabditis elegans. Overexpression of SIRT1 in cancer tissue, compared with normal tissue, has been demonstrated, suggesting that SIRT1 may act as a tumor promoter. The function of SIRT1 in liver cancer has not been elucidated. In the present study, SIRT1 re-expression or knockdown was induced in hepatoma cell lines and liver normal cell lines. Our study demonstrated that overexpression of SIRT1 promoted mitotic entry of liver cells, cell growth and proliferation and inhibited apoptosis. The apoptosis involved caspase-3 and caspase-7, and was related to the PTEN/PI3K/AKT signaling pathway. The results demonstrate that SIRT1 promotes tumorigenesis of hepatocellular carcinoma (HCC) through the PTEN/PI3K/AKT signaling pathway. SIRT1 may serve as a novel target for selective killing of cancer versus normal liver cells.

Author(s): 
Wang, Hanning
Liu, Hao
Chen, Kaiyun
Xiao, Jinfeng
He, Ke
Zhang, Jinqian
Xiang, Guoan
Item Type: 
Journal Article
Publication Title: 
Oncology Reports
Journal Abbreviation: 
Oncol. Rep.
Publication Date: 
2012-07
Publication Year: 
2012
Pages: 
311-318
Volume: 
28
Issue: 
1
ISSN: 
1791-2431
DOI: 
10.3892/or.2012.1788
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 22552445

Turabian/Chicago Citation

Hanning Wang, Hao Liu, Kaiyun Chen, Jinfeng Xiao, Ke He, Jinqian Zhang and Guoan Xiang. 2012-07. "SIRT1 promotes tumorigenesis of hepatocellular carcinoma through PI3K/PTEN/AKT signaling." Oncology Reports 28: 1: 311-318. 10.3892/or.2012.1788.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.3892/or.2012.1788 | issn = 1791-2431 | volume = 28 | pages = 311-318 | last = Wang | first = Hanning | coauthors = Liu, Hao, Chen, Kaiyun, Xiao, Jinfeng, He, Ke, Zhang, Jinqian, Xiang, Guoan | title = SIRT1 promotes tumorigenesis of hepatocellular carcinoma through PI3K/PTEN/AKT signaling | journal = Oncology Reports | date = 2012-07 | pmid = | pmc = }} </ref>