Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans
Language: 
English
Abstract: 

The nematode Caenorhabditis elegans is an important model for studying the genetics of ageing, with over 50 life-extension mutations known so far. However, little is known about the pathobiology of ageing in this species, limiting attempts to connect genotype with senescent phenotype. Using ultrastructural analysis and visualization of specific cell types with green fluorescent protein, we examined cell integrity in different tissues as the animal ages. We report remarkable preservation of the nervous system, even in advanced old age, in contrast to a gradual, progressive deterioration of muscle, resembling human sarcopenia. The age-1(hx546) mutation, which extends lifespan by 60-100%, delayed some, but not all, cellular biomarkers of ageing. Strikingly, we found strong evidence that stochastic as well as genetic factors are significant in C. elegans ageing, with extensive variability both among same-age animals and between cells of the same type within individuals.

Author(s): 
Herndon, Laura A.
Schmeissner, Peter J.
Dudaronek, Justyna M.
Brown, Paula A.
Listner, Kristin M.
Sakano, Yuko
Paupard, Marie C.
Hall, David H.
Driscoll, Monica
Item Type: 
Journal Article
Publication Title: 
Nature
Journal Abbreviation: 
Nature
Publication Date: 
10/24/2002
Publication Year: 
2002
Pages: 
808-814
Volume: 
419
Issue: 
6909
ISSN: 
0028-0836
DOI: 
10.1038/nature01135
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 12397350

Turabian/Chicago Citation

Laura A. Herndon, Peter J. Schmeissner, Justyna M. Dudaronek, Paula A. Brown, Kristin M. Listner, Yuko Sakano, Marie C. Paupard, David H. Hall and Monica Driscoll. 10/24/2002. "Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans." Nature 419: 6909: 808-814. 10.1038/nature01135.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1038/nature01135 | issn = 0028-0836 | volume = 419 | pages = 808-814 | last = Herndon | first = Laura A. | coauthors = Schmeissner, Peter J., Dudaronek, Justyna M., Brown, Paula A., Listner, Kristin M., Sakano, Yuko, Paupard, Marie C., Hall, David H., Driscoll, Monica | title = Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans | journal = Nature | date = 10/24/2002 | pmid = | pmc = }} </ref>