Study of anti-inflammatory activity in the leaves of Nyctanthes arbor tristis Linn.--an Indian medicinal plant
Language: 
English
Abstract: 

Nyctanthes arbor tristis Linn. (Harsingar) is widely used as a decoction in the Ayurvedic system of medicine for treatment of sciatica and arthritis, but it has not yet been screened scientifically. In the present study, the water soluble portion of the alcoholic extract of the leaves of Nyctanthes arbor tristis (NAT) was screened for the presence of anti-inflammatory activity. NAT inhibited the acute inflammatory oedema produced by different phlogistic agents, viz. carrageenin, formalin, histamine, 5-hydroxytryptamine and hyaluronidase in the hindpaw of rats. The acute inflammatory swelling in the knee joint of rats induced by turpentine oil was also significantly reduced. In subacute models, NAT was found to check granulation tissue formation significantly in the granuloma pouch and cotton pellet test. Acute and chronic phases of formaldehyde induced arthritis were significantly inhibited. NAT was also found to inhibit the inflammation produced by immunological methods, viz. Freund's adjuvant arthritis and PPD induced tuberculin reaction. Thus anti-inflammatory activity in leaves of Harsingar supports its use in various inflammatory conditions by the followers of the Ayurvedic system of medicine.

Author(s): 
Saxena, R. S.
Gupta, B.
Saxena, K. K.
Singh, R. C.
Prasad, D. N.
Item Type: 
Journal Article
Publication Title: 
Journal of Ethnopharmacology
Journal Abbreviation: 
J Ethnopharmacol
Publication Date: 
Aug 1984
Publication Year: 
1984
Pages: 
319-330
Volume: 
11
Issue: 
3
ISSN: 
0378-8741
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 6482481

Turabian/Chicago Citation

R. S. Saxena, B. Gupta, K. K. Saxena, R. C. Singh and D. N. Prasad. Aug 1984. "Study of anti-inflammatory activity in the leaves of Nyctanthes arbor tristis Linn.--an Indian medicinal plant." Journal of Ethnopharmacology 11: 3: 319-330.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 0378-8741 | volume = 11 | pages = 319-330 | last = Saxena | first = R. S. | coauthors = Gupta, B., Saxena, K. K., Singh, R. C., Prasad, D. N. | title = Study of anti-inflammatory activity in the leaves of Nyctanthes arbor tristis Linn.--an Indian medicinal plant | journal = Journal of Ethnopharmacology | date = Aug 1984 | pmid = | pmc = }} </ref>