Susceptibility of Thai isolates of Plasmodium falciparum to artemisinine (qinghaosu) and artemether
Language: 
English
Abstract: 

Eleven Thai isolates and one West African isolate of Plasmodium falciparum were tested for their susceptibility to the Chinese antimalarial drugs artemisinine (qinghaosu) and artemether. The isolates were cultivated by the Trager-Jensen candle-jar technique and exposed to the action of the drugs for 36-48 hours. Artemisinine inhibited growth of most isolates at 10(-7)-10(-8) mol/litre and artemether at 10(-8) mol/litre (with an initial parasitaemia of 0.5-1.0%). Slight variation in the sensitivity of different isolates was found, but there was no correlation between sensitivity to artemisinine or artemether and sensitivity to pyrimethamine, pyrimethamine/sulfadoxine, or chloroquine. The action of artemisinine and artemether was reduced when the initial parasitaemia of the treated cultures was raised.

Author(s): 
Thaithong, S.
Beale, G. H.
Item Type: 
Journal Article
Publication Title: 
Bulletin of the World Health Organization
Journal Abbreviation: 
Bull. World Health Organ.
Publication Date: 
1985
Publication Year: 
1985
Pages: 
617-619
Volume: 
63
Issue: 
3
ISSN: 
0042-9686
Library Catalog: 
PubMed
Extra: 
PMID: 3899399 PMCID: PMC2536412

Turabian/Chicago Citation

S. Thaithong and G. H. Beale. 1985. "Susceptibility of Thai isolates of Plasmodium falciparum to artemisinine (qinghaosu) and artemether." Bulletin of the World Health Organization 63: 3: 617-619.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 0042-9686 | volume = 63 | pages = 617-619 | last = Thaithong | first = S. | coauthors = Beale, G. H. | title = Susceptibility of Thai isolates of Plasmodium falciparum to artemisinine (qinghaosu) and artemether | journal = Bulletin of the World Health Organization | date = 1985 | pmid = | pmc = }} </ref>