Synthesis of protopanaxadiol derivatives and evaluation of their anticancer activities
Language: 
English
Abstract: 

Protopanaxadiol (PPD), an aglycon of ginseng saponins, has shown anticancer activity in earlier studies. Here, we have reported the semisynthesis of nine PPD derivatives with acetyl substitutions. Subsequently, the antiproliferative effects of these nine analogs on different human cancer cell lines have been investigated. Compounds 1, 3, and 5 showed more significant and more potent antiproliferative activity compared with PPD and other derivatives. A flow cytometric assay indicated that compounds 1, 3, and 5 arrested cell cycle progression in the G1 phase and significantly induced apoptosis of cancer cells.

Author(s): 
Du, Guang-Jian
Dai, Qing
Williams, Stainley
Wang, Chong-Zhi
Yuan, Chun-Su
Item Type: 
Journal Article
Publication Title: 
Anti-Cancer Drugs
Journal Abbreviation: 
Anticancer Drugs
Publication Date: 
Jan 2011
Publication Year: 
2011
Pages: 
35-45
Volume: 
22
Issue: 
1
ISSN: 
1473-5741
DOI: 
10.1097/CAD.0b013e32833fde29
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 20926945 PMCID: PMC2992804

Turabian/Chicago Citation

Guang-Jian Du, Qing Dai, Stainley Williams, Chong-Zhi Wang and Chun-Su Yuan. Jan 2011. "Synthesis of protopanaxadiol derivatives and evaluation of their anticancer activities." Anti-Cancer Drugs 22: 1: 35-45. 10.1097/CAD.0b013e32833fde29.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1097/CAD.0b013e32833fde29 | issn = 1473-5741 | volume = 22 | pages = 35-45 | last = Du | first = Guang-Jian | coauthors = Dai, Qing, Williams, Stainley, Wang, Chong-Zhi, Yuan, Chun-Su | title = Synthesis of protopanaxadiol derivatives and evaluation of their anticancer activities | journal = Anti-Cancer Drugs | date = Jan 2011 | pmid = | pmc = }} </ref>