Telomerase reverse transcriptase synergizes with calorie restriction to increase health span and extend mouse longevity
Language: 
English
Abstract: 

Caloric restriction (CR), a reduction of food intake while avoiding malnutrition, can delay the onset of cancer and age-related diseases in several species, including mice. In addition, depending of the genetic background, CR can also increase or decrease mouse longevity. This has highlighted the importance of identifying the molecular pathways that interplay with CR in modulating longevity. Significant lifespan extension in mice has been recently achieved through over-expression of the catalytic subunit of mouse telomerase (mTERT) in a cancer protective background. Given the CR cancer-protective effects in rodents, we set to address here whether CR impacts on telomere length and synergizes with mTERT to extend mouse longevity. CR significantly decreased tumor incidence in TERT transgenic (TgTERT) mice and extended their lifespan compared to wild-type (WT) controls under the same diet, indicating a synergy between TgTERT and CR in increasing mouse longevity. In addition, longitudinal telomere length measurements in peripheral blood leukocytes from individual mice showed that CR resulted in maintenance and/or elongation telomeres in a percentage of WT mice, a situation that mimics telomere dynamics in TgTERT cohorts. These results demonstrate that CR attenuates telomere erosion associated to aging and that synergizes with TERT over-expression in increasing "health span" and extending mouse longevity.

Author(s): 
Vera, Elsa
Bernardes de Jesus, Bruno
Foronda, Miguel
Flores, Juana M.
Blasco, Maria A.
Item Type: 
Journal Article
Publication Title: 
PloS One
Journal Abbreviation: 
PLoS ONE
Publication Date: 
2013
Publication Year: 
2013
Pages: 
e53760
Volume: 
8
Issue: 
1
ISSN: 
1932-6203
DOI: 
10.1371/journal.pone.0053760
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 23349740 PMCID: PMC3551964

Turabian/Chicago Citation

Elsa Vera, Bruno Bernardes de Jesus, Miguel Foronda, Juana M. Flores and Maria A. Blasco. 2013. "Telomerase reverse transcriptase synergizes with calorie restriction to increase health span and extend mouse longevity." PloS One 8: 1: e53760. 10.1371/journal.pone.0053760.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1371/journal.pone.0053760 | issn = 1932-6203 | volume = 8 | pages = e53760 | last = Vera | first = Elsa | coauthors = Bernardes de Jesus, Bruno, Foronda, Miguel, Flores, Juana M., Blasco, Maria A. | title = Telomerase reverse transcriptase synergizes with calorie restriction to increase health span and extend mouse longevity | journal = PloS One | date = 2013 | pmid = | pmc = }} </ref>