Test-retest, within-visit variability of Goldmann visual fields in retinitis pigmentosa

PURPOSE: Reliable outcome measures are needed to estimate changes in peripheral vision during future treatment clinical trials for retinal degeneration patients. The authors examined the short-term variability of Goldmann visual field (GVF) results converted to retinal areas in retinitis pigmentosa (RP) subjects. METHODS: Two within-visit GVFs were obtained from one eye each of 37 RP subjects with visual acuity better than 20/400 by a single experienced operator using the V4e (n = 28) or III4e (n = 12) target, or both. Planimetric GVF measures were digitized and converted to retinal areas in square millimeters by a single independent user. The 95% coefficient of repeatability (CR.(95)) for percentage change in central retinal area was determined from the test-retest difference. RESULTS: There were no significant systematic trends toward either increase or decrease between the first and second GVF. For the III4e target, the CR.(95) was 23.7% on average across all 12 subjects. For the V4e target, the CR.(95) was 32.8% on average across all 28 subjects. However, 3 of 8 subjects with a geometric mean retinal area <10 mm(2) (∼7° radius) for the V4e target exhibited unusually large variability (50%-100%), and the CR.(95) was 19.2% when these three subjects were excluded. Variability was not statistically significantly related to visual acuity, age, presence of cystoid macular edema, or subjects' stress or anxiety levels. CONCLUSIONS: Inherent test-retest variability (CR.(95)) of functional retinal areas derived from GVF results in a clinical RP population can be limited to <20% by using a single experienced operator, making the GVF the measure of choice for changes in peripheral vision.

Bittner, Ava K.
Iftikhar, Mian Haris
Dagnelie, Gislin
Item Type: 
Journal Article
Publication Title: 
Investigative Ophthalmology & Visual Science
Journal Abbreviation: 
Invest. Ophthalmol. Vis. Sci.
Publication Date: 
Publication Year: 
Library Catalog: 
NCBI Published Medical (?)
PMID: 21896857 PMCID: PMC3208001

Turabian/Chicago Citation

Ava K. Bittner, Mian Haris Iftikhar and Gislin Dagnelie. 2011. "Test-retest, within-visit variability of Goldmann visual fields in retinitis pigmentosa." Investigative Ophthalmology & Visual Science 52: 11: 8042-8046. 10.1167/iovs.11-8321.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1167/iovs.11-8321 | issn = 1552-5783 | volume = 52 | pages = 8042-8046 | last = Bittner | first = Ava K. | coauthors = Iftikhar, Mian Haris, Dagnelie, Gislin | title = Test-retest, within-visit variability of Goldmann visual fields in retinitis pigmentosa | journal = Investigative Ophthalmology & Visual Science | date = 2011 | pmid = | pmc = }} </ref>