[Tizanidine for preanesthetic medication]
Language: 
Japanese
Abstract: 

The effect of tizanidine given as a premedication on perioperative hemodynamics (mean blood pressure, heart rate), sedation, hypnosis and midazolam requirements for induction were assessed in 68 patients scheduled for elective surgery under general anesthesia. Patients were assigned to three groups. Group 1 was premedicated 90 min prior to induction with tizanidine 4 mg po (n = 28); group 2 was premedicated with tizanidine 2 mg po (n = 12); group 3 received no premedication (n = 28). In group 1, increase of mean blood pressure on anesthesia induction was attenuated significantly and sedative and hypnotic effects were stronger significantly compared with other groups. We also found that the amounts of midazolam necessary for loss of consciousness were significantly less in patients who had received tizanidine 4 mg. In conclusion, tizanidine is a useful drug as preanesthetic medication for general anesthesia.

Author(s): 
Takenaka, M.
Iida, H.
Kasamatsu, M.
Katoh, H.
Tashiro, T.
Dohi, S.
Item Type: 
Journal Article
Publication Title: 
Masui. The Japanese Journal of Anesthesiology
Journal Abbreviation: 
Masui
Publication Date: 
Aug-96
Publication Year: 
1996
Pages: 
971-975
Volume: 
45
Issue: 
8
ISSN: 
0021-4892
Library Catalog: 
PubMed
Extra: 
PMID: 8818094

Turabian/Chicago Citation

M. Takenaka, H. Iida, M. Kasamatsu, H. Katoh, T. Tashiro and S. Dohi. Aug-96. "[Tizanidine for preanesthetic medication]." Masui. The Japanese Journal of Anesthesiology 45: 8: 971-975.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 0021-4892 | volume = 45 | pages = 971-975 | last = Takenaka | first = M. | coauthors = Iida, H., Kasamatsu, M., Katoh, H., Tashiro, T., Dohi, S. | title = [Tizanidine for preanesthetic medication] | journal = Masui. The Japanese Journal of Anesthesiology | date = Aug-96 | pmid = | pmc = }} </ref>