Tolerance induced by chronic inhaled antigen in a murine asthma model is not mediated by endotoxin
Language: 
English
Abstract: 

Ovalbumin (OVA)-sensitized wildtype (WT) and endotoxin-resistant (ER) mice developed similar degrees of airways eosinophilia and serum OVA-specific IgE levels after acute aerosolized OVA challenge. WT mice demonstrated methacholine hyperreactivity, whereas ER mice showed no change in responsiveness. With chronic aerosolized OVA challenge, both WT and ER mice developed local tolerance, with resolution of airway eosinophilia but persistence of anti-OVA IgE in serum. Thus, the development of local tolerance with chronic aerosol exposure to OVA is independent of any potential effects of endotoxin in the OVA aerosol solution.

Author(s): 
Schramm, C. M.
Guernsey, L.
Secor, E.
Thrall, R. S.
Item Type: 
Journal Article
Publication Title: 
Biochimica Et Biophysica Acta
Journal Abbreviation: 
Biochim. Biophys. Acta
Publication Date: 
May 2006
Publication Year: 
2006
Pages: 
499-501
Volume: 
1762
Issue: 
5
ISSN: 
0006-3002
DOI: 
10.1016/j.bbadis.2006.02.002
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 16616459

Turabian/Chicago Citation

C. M. Schramm, L. Guernsey, E. Secor and R. S. Thrall. May 2006. "Tolerance induced by chronic inhaled antigen in a murine asthma model is not mediated by endotoxin." Biochimica Et Biophysica Acta 1762: 5: 499-501. 10.1016/j.bbadis.2006.02.002.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.bbadis.2006.02.002 | issn = 0006-3002 | volume = 1762 | pages = 499-501 | last = Schramm | first = C. M. | coauthors = Guernsey, L., Secor, E., Thrall, R. S. | title = Tolerance induced by chronic inhaled antigen in a murine asthma model is not mediated by endotoxin | journal = Biochimica Et Biophysica Acta | date = May 2006 | pmid = | pmc = }} </ref>