Triphala, a formulation of traditional Ayurvedic medicine, shows protective effect against X-radiation in HeLa cells
Language: 
English
Abstract: 

Ayurveda is a holistic medical system of traditional medicine, and Triphala is one of the most popular formulations in Ayurveda. Triphala is composed of three kinds of herb, Terminalia chebula, Terminalia bellirica, and Emblica officinalis. Since Triphala is shown to exhibit a protective activity against ionizing radiation in mice, we investigated its activity in HeLa cells. We found that Triphala showed the protective effects against X-radiation and bleomycin, both of which generate DNA strand breaks, in HeLa cells. Further, Triphala efficiently eliminated reactive oxygen species (ROS) in HeLa cells. Thus, the antioxidant activity of Triphala would likely play a role in its protective actions against X-radiation and bleomycin because both agents damage DNA through the generation of ROS. These observations suggested that the radioprotective activity of Triphala can be, at least partly, studied with the cells cultured in vitro. The simple bioassay system with human cultured cells would facilitate the understanding of the molecular basis for the beneficial effects of Triphala.

Author(s): 
Takauji, Yuki
Miki, Kensuke
Mita, Juma
Hossain, Mohammad Nazir
Yamauchi, Masatake
Kioi, Mitomu
Ayusawa, Dai
Fujii, Michihiko
Item Type: 
Journal Article
Publication Title: 
Journal of Biosciences
Journal Abbreviation: 
J. Biosci.
Publication Date: 
2016-12
Publication Year: 
2016
Pages: 
569-575
Volume: 
41
Issue: 
4
ISSN: 
0973-7138
Library Catalog: 
PubMed
Extra: 
PMID: 27966480

Turabian/Chicago Citation

Yuki Takauji, Kensuke Miki, Juma Mita, Mohammad Nazir Hossain, Masatake Yamauchi, Mitomu Kioi, Dai Ayusawa and Michihiko Fujii. 2016-12. "Triphala, a formulation of traditional Ayurvedic medicine, shows protective effect against X-radiation in HeLa cells." Journal of Biosciences 41: 4: 569-575.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 0973-7138 | volume = 41 | pages = 569-575 | last = Takauji | first = Yuki | coauthors = Miki, Kensuke, Mita, Juma, Hossain, Mohammad Nazir, Yamauchi, Masatake, Kioi, Mitomu, Ayusawa, Dai, Fujii, Michihiko | title = Triphala, a formulation of traditional Ayurvedic medicine, shows protective effect against X-radiation in HeLa cells | journal = Journal of Biosciences | date = 2016-12 | pmid = | pmc = }} </ref>