Understanding the determinants of exceptional longevity
Language: 
English
Abstract: 

Centenarians represent an extreme of life expectancy. They achieve their exceptional longevity in part by lacking genetic variations linked to premature death. Pedigree studies have shown a substantial familial component in the ability to survive to extreme old age, and a recent study demonstrated a locus on chromosome 4 linked to exceptional longevity, indicating the likely existence of at least one longevity-enabling gene in humans. The children of centenarians have markedly reduced relative risks for age-related diseases, particularly heart disease, hypertension, and diabetes, and are a promising model for genetic and phenotypic studies of 1) aging slowly relative to the general population and 2) the delay of and perhaps escape from important age-related diseases. These studies and those of other mammals and lower organisms show great promise for the delineation of important environmental and genetic determinants of aging well.

Author(s): 
Perls, Thomas
Terry, Dellara
Item Type: 
Journal Article
Publication Title: 
Annals of Internal Medicine
Journal Abbreviation: 
Ann. Intern. Med.
Publication Date: 
9/2/2003
Publication Year: 
2003
Pages: 
445-449
Volume: 
139
Issue: 
5 Pt 2
ISSN: 
1539-3704
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 12965974

Turabian/Chicago Citation

Thomas Perls and Dellara Terry. 9/2/2003. "Understanding the determinants of exceptional longevity." Annals of Internal Medicine 139: 5 Pt 2: 445-449.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 1539-3704 | volume = 139 | pages = 445-449 | last = Perls | first = Thomas | coauthors = Terry, Dellara | title = Understanding the determinants of exceptional longevity | journal = Annals of Internal Medicine | date = 9/2/2003 | pmid = | pmc = }} </ref>