In vitro activity of artemether against African isolates (Senegal) of Plasmodium falciparum in comparison with standard antimalarial drugs
Language: 
English
Abstract: 

The in vitro activity of artemether against 56 African isolates of Plasmodium falciparum from Senegal was evaluated using an isotope-based drug susceptibility semi-microtest. The 50% inhibitory concentration (IC50) values for artemether were in a narrow range from 0.8 to 15.2 nM (mean IC50 = 3.43 nM) and the 95% confidence interval (CI) was 2.50-4.36 nM. Artemether was equally effective on chloroquine-sensitive and chloroquine-resistant isolates (mean IC50 = 346 nM, 95% CI = 2.08-4.84 nM versus mean IC50 = 2.80 nM, 95% CI = 2.00-3.60 nM). There was a significant positive correlation between responses to artemether and mefloquine (r2 = 0.36, P < 0.001), artemether and quinine (r2 = 0.085, P < 0.05), artemether and halofantrine (r2 = 0.075, P < 0.05), quinine and mefloquine (r2 = 0.205, P < 0.01), quinine and halofantrine (r2 = 0.124, P < 0.05), and mefloquine and halofantrine (r2 = 0.801, P < 0.001). A positive correlation between these drugs suggests in vitro cross-resistance or at least in vitro cross-susceptibility.

Author(s): 
Pradines, B.
Rogier, C.
Fusai, T.
Tall, A.
Trape, J. F.
Doury, J. C.
Item Type: 
Journal Article
Publication Title: 
The American Journal of Tropical Medicine and Hygiene
Journal Abbreviation: 
Am. J. Trop. Med. Hyg.
Publication Date: 
Mar-98
Publication Year: 
1998
Pages: 
354-357
Volume: 
58
Issue: 
3
ISSN: 
0002-9637
Library Catalog: 
PubMed
Extra: 
PMID: 9546418

Turabian/Chicago Citation

B. Pradines, C. Rogier, T. Fusai, A. Tall, J. F. Trape and J. C. Doury. Mar-98. "In vitro activity of artemether against African isolates (Senegal) of Plasmodium falciparum in comparison with standard antimalarial drugs." The American Journal of Tropical Medicine and Hygiene 58: 3: 354-357.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 0002-9637 | volume = 58 | pages = 354-357 | last = Pradines | first = B. | coauthors = Rogier, C., Fusai, T., Tall, A., Trape, J. F., Doury, J. C. | title = In vitro activity of artemether against African isolates (Senegal) of Plasmodium falciparum in comparison with standard antimalarial drugs | journal = The American Journal of Tropical Medicine and Hygiene | date = Mar-98 | pmid = | pmc = }} </ref>