In vitro modeling of repetitive motion strain and manual medicine treatments: potential roles for pro- and anti-inflammatory cytokines
Language: 
English
Short Title: 
In vitro modeling of repetitive motion strain and manual medicine treatments
Abstract: 

Despite positive clinical outcomes documented post-treatment with a variety of manual medicine treatments (MMT), the underlying cellular mechanisms responsible remain elusive. We have developed an in vitro human fibroblast cell system used to model various biomechanical strains that human fibroblasts might undergo in response to repetitive motion strain (RMS) and MMT. Our data utilizing this system suggest that RMS induces disruption of cell-cell and cell-matrix contacts, which appear are reversed when a modeled MMT is also added to the treatment protocol. Similarly, while RMS induces secretion of several inflammatory cytokines, modeled MMT attenuates this secretory response. In terms of strain direction, fibroblasts strained equiradially exhibit unique cytokine secretory profiles vs. those strained heterobiaxially. Taken together, these data suggest that this cell model may prove useful in identifying the cellular mechanisms by which various fascial strains used clinically to treat somatic dysfunctions yield positive clinical outcomes such as reduced pain, reduced analgesic use and improved range of motion.

Author(s): 
Standley, Paul R.
Meltzer, Kate
Item Type: 
Journal Article
Publication Title: 
Journal of Bodywork and Movement Therapies
Journal Abbreviation: 
J Bodyw Mov Ther
Publication Date: 
Jul 2008
Publication Year: 
2008
Pages: 
201-203
Volume: 
12
Issue: 
3
ISSN: 
1532-9283
DOI: 
10.1016/j.jbmt.2008.05.006
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 19083676 PMCID: PMC2622428

Turabian/Chicago Citation

Paul R. Standley and Kate Meltzer. Jul 2008. "In vitro modeling of repetitive motion strain and manual medicine treatments: potential roles for pro- and anti-inflammatory cytokines." Journal of Bodywork and Movement Therapies 12: 3: 201-203. 10.1016/j.jbmt.2008.05.006.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.jbmt.2008.05.006 | issn = 1532-9283 | volume = 12 | pages = 201-203 | last = Standley | first = Paul R. | coauthors = Meltzer, Kate | title = In vitro modeling of repetitive motion strain and manual medicine treatments: potential roles for pro- and anti-inflammatory cytokines | journal = Journal of Bodywork and Movement Therapies | date = Jul 2008 | pmid = | pmc = }} </ref>