Yeast as a model to study mitochondrial mechanisms in ageing
Language: 
English
Abstract: 

Despite the fact that ageing necessarily displays unique aspects in a single-cell organism, yeast, in particular Saccharomyces cerevisiae, are useful as model organisms to study ageing. Here we review mitochondrial characteristics involved in yeast longevity, including biogenesis, autophagy, respiration and oxidative phosphorylation, nutrient sensing, mitochondria-nuclear signaling, redox state and mitochondrial DNA integrity. Altogether, the yeast model unearths a rich and complex network involving many mitochondrial functions in ageing, and uncovers physiological and genetic mechanisms capable of extending lifespan in this model which may be shared with more complex organisms.

Author(s): 
Barros, Mario H.
da Cunha, Fernanda M.
Oliveira, Graciele A.
Tahara, Erich B.
Kowaltowski, Alicia J.
Item Type: 
Journal Article
Publication Title: 
Mechanisms of Ageing and Development
Journal Abbreviation: 
Mech. Ageing Dev.
Publication Date: 
2010-08
Publication Year: 
2010
Pages: 
494-502
Volume: 
131
Issue: 
8-Jul
ISSN: 
1872-6216
DOI: 
10.1016/j.mad.2010.04.008
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 20450928

Turabian/Chicago Citation

Mario H. Barros, Fernanda M. da Cunha, Graciele A. Oliveira, Erich B. Tahara and Alicia J. Kowaltowski. 2010-08. "Yeast as a model to study mitochondrial mechanisms in ageing." Mechanisms of Ageing and Development 131: 8-Jul: 494-502. 10.1016/j.mad.2010.04.008.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.mad.2010.04.008 | issn = 1872-6216 | volume = 131 | pages = 494-502 | last = Barros | first = Mario H. | coauthors = da Cunha, Fernanda M., Oliveira, Graciele A., Tahara, Erich B., Kowaltowski, Alicia J. | title = Yeast as a model to study mitochondrial mechanisms in ageing | journal = Mechanisms of Ageing and Development | date = 2010-08 | pmid = | pmc = }} </ref>