Zinc absorption and zinc status are reduced after Roux-en-Y gastric bypass: a randomized study using 2 supplements
Language: 
English
Short Title: 
Zinc absorption and zinc status are reduced after Roux-en-Y gastric bypass
Abstract: 

BACKGROUND: Micronutrient deficiencies are common in patients undergoing gastric bypass. The effect of this type of surgery on zinc absorption and zinc status is not well known. OBJECTIVE: The objective was to evaluate the effects of Roux-en-Y gastric bypass (RYGBP) on zinc status and zinc absorption at different stages after surgery. We hypothesized that zinc status would be significantly impaired after surgery and that this impairment would be less severe in subjects receiving increased supplemental zinc. We also hypothesized that zinc absorption would be lower after surgery. DESIGN: Anthropometric and body-composition variables and dietary and biochemical indexes of zinc status and zinc absorption were determined in 67 severe and morbidly obese women [mean (±SD) age: 36.9 ± 9.8 y; BMI (in kg/m(2)): 45.2 ± 4.7] who underwent RYGBP. The subjects were randomly assigned to 1 of 2 vitamin-mineral supplementation groups. Measurements were made before and 6, 12, and 18 mo after surgery. Fifty-six subjects completed the 18-mo follow-up. RESULTS: Mean plasma zinc, erythrocyte membrane alkaline phosphatase activity, and the size of the rapidly exchangeable zinc pool decreased after RYGBP. Percentage zinc absorption decreased significantly from 32.3% to 13.6% at 6 mo after RYGBP and to 21% at 18 mo after surgery. No effect of supplement type was observed. CONCLUSIONS: Zinc status is impaired after RYGBP, despite the finding that dietary plus supplemental zinc doubled recommended zinc intakes in healthy persons. Zinc absorption capacity is significantly reduced soon after RYGBP, with no major changes until 18 mo after surgery.

Author(s): 
Ruz, Manuel
Carrasco, Fernando
Rojas, Pamela
Codoceo, Juana
Inostroza, Jorge
Basfi-fer, Karen
Csendes, Attila
Papapietro, Karin
Pizarro, Fernando
Olivares, Manuel
Sian, Lei
Westcott, Jamie L.
Miller, Leland V.
Hambidge, K. Michael
Krebs, Nancy F.
Item Type: 
Journal Article
Publication Title: 
The American Journal of Clinical Nutrition
Journal Abbreviation: 
Am. J. Clin. Nutr.
Publication Date: 
Oct 2011
Publication Year: 
2011
Pages: 
1004-1011
Volume: 
94
Issue: 
4
ISSN: 
1938-3207
DOI: 
10.3945/ajcn.111.018143
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 21865332

Turabian/Chicago Citation

Manuel Ruz, Fernando Carrasco, Pamela Rojas, Juana Codoceo, Jorge Inostroza, Karen Basfi-fer, Attila Csendes, Karin Papapietro, Fernando Pizarro, Manuel Olivares, Lei Sian, Jamie L. Westcott, Leland V. Miller, K. Michael Hambidge and Nancy F. Krebs. Oct 2011. "Zinc absorption and zinc status are reduced after Roux-en-Y gastric bypass: a randomized study using 2 supplements." The American Journal of Clinical Nutrition 94: 4: 1004-1011. 10.3945/ajcn.111.018143.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.3945/ajcn.111.018143 | issn = 1938-3207 | volume = 94 | pages = 1004-1011 | last = Ruz | first = Manuel | coauthors = Carrasco, Fernando, Rojas, Pamela, Codoceo, Juana, Inostroza, Jorge, Basfi-fer, Karen, Csendes, Attila, Papapietro, Karin, Pizarro, Fernando, Olivares, Manuel, Sian, Lei, Westcott, Jamie L., Miller, Leland V., Hambidge, K. Michael, Krebs, Nancy F. | title = Zinc absorption and zinc status are reduced after Roux-en-Y gastric bypass: a randomized study using 2 supplements | journal = The American Journal of Clinical Nutrition | date = Oct 2011 | pmid = | pmc = }} </ref>