3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester

Publication Title: 
Anesthesia and Analgesia

Our study examined whether calcium channels are involved in the anesthetic action of dexmedetomidine (100-300 micrograms/kg), a highly selective alpha 2-adrenoceptor agonist. To investigate this, we studied the effects of verapamil (1.25 or 2.5 mg/kg), a calcium channel blocker, and BAY K8644 (0.5 or 1 mg/kg), a calcium channel agonist, on the hypnotic-anesthetic effect of dexmedetomidine in rats. Loss of the righting reflex was used to determine the presence of anesthesia, and its length in minutes was referred to as the duration of hypnosis.

Author(s): 
Horvàth, G.
Szikszay, M.
Benedek, G.
Publication Title: 
American Journal of Physiology. Heart and Circulatory Physiology

External application of static magnetic fields (SMF), used specifically for the treatment of inflammatory conditions such as soft tissue injuries, has recently become popular as a complementary and/or alternative therapy with minimal investigation into efficacy or mechanism. Localized inflammation was induced via injection of inflammatory agents lambda-carrageenan (CA) or histamine into rat hindpaws, alone or in conjunction with pharmacological agents, resulting in a spatially and temporally defined inflammatory reaction.

Author(s): 
Morris, Cassandra E.
Skalak, Thomas C.
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: Brazilian folk medicine uses infusion of Costus spiralis leaf to help people to treat arterial hypertension and syndromes of cardiac hyperexcitability. AIM OF THE STUDY: Evaluate the aqueous fraction (AqF) effect on atrial contractility and investigate its mechanism of action. MATERIALS AND METHODS: The AqF effect on the cardiac contractility was studied on isolated electrically driven guinea pig left atria. Atropine and tetraethylammonium (TEA) were employed to investigate whether potassium contributes for the inotropic mechanism of the AqF.

Author(s): 
Britto, Raquel Moreira
Santos, André Luiz
Cruz, Jader Santos
Gondim, Antonio Nei Santana
Lauton-Santos, Sandra
Lara, Aline
Guatimosim, Silvia
Vasconcelos, Carla Maria Lins
Estevam, Charles Dos Santos
Dias, Antonio Santos
Oliveira, Evaleide Diniz
Lima, Adriana Karla
Souza, Rejane Cardoso
Conde-Garcia, Eduardo Antonio
Publication Title: 
American Journal of Physiology. Endocrinology and Metabolism

Dysmenorrhea is directly related to elevated PGF(2alpha) levels. It is treated with nonsteroid antiinflammatory drugs (NSAIDs) in Western medicine. Since NSAIDs produce many side effects, Chinese medicinal therapy is considered as a feasible alternative medicine. Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf.) has been used as a traditional Chinese medicine for treating dysmenorrhea. However, the relationship between smooth muscle contraction and adlay extracts remains veiled.

Author(s): 
Hsia, Shih-Min
Kuo, Yueh-Hsiung
Chiang, Wenchang
Wang, Paulus S.
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