Publication Title: 
Journal of Neural Transmission (Vienna, Austria: 1996)

In order to elucidate the mechanism(s) behind the interactions between barbiturates and Ca(2+) antagonists, the effects of three structurally diverse types of Ca(2+) antagonists combined or not with 5-HT on pentobarbital-induced hypnosis in mice were investigated.

Zhao, X.
Cui, X.-Y.
Chu, Q.-P.
Chen, B.-Q.
Wang, X.-M.
Lin, Z.-B.
Li, X.-J.
Ku, B.-S.
Zhang, Y.-H.
Publication Title: 
Journal of Ethnopharmacology

AIM OF THE STUDY: Marsilea minuta Linn. (Marsileaceae) has been referred in Indian traditional medicine system (Ayurveda) for the treatment of insomnia and other mental disorders. Marsiline isolated from Marsilea minuta was reported to have sedative and anticonvulsant property. The ethanol extract of Marsilea minuta was standardised for marsiline (1.15%, w/w) and studied for its antidepressant activity.

Bhattamisra, Subrat Kumar
Khanna, Vinay Kumar
Agrawal, Ashok Kumar
Singh, Paras Nath
Singh, Sushil Kumar
Publication Title: 
Pharmacology, Biochemistry, and Behavior

Asparagus racemosus Linn. (AR) is an Ayurvedic rasayana used as an adaptogen. Adaptogenic drugs are those which are useful as anti-stress agents by promoting non-specific resistance of the body. Although, the adaptogenic effect of AR is well documented, its use in psychological disorders like depression is not scientifically evaluated. Hence, the present investigation evaluates the antidepressant effect of methanolic extract of roots of AR (MAR) standardized to saponins (62.2% w/w).

Singh, Gireesh K.
Garabadu, Debapriya
Muruganandam, A. V.
Joshi, Vinod K.
Krishnamurthy, Sairam
Publication Title: 
American Journal of Physiology. Lung Cellular and Molecular Physiology

Clinical reports indicate that patients with allergy/asthma commonly have associated symptoms of anxiety/depression. Anxiety/depression can be reduced by 5-hydroxytryptophan (5-HTP) supplementation. However, it is not known whether 5-HTP reduces allergic inflammation. Therefore, we determined whether 5-HTP supplementation reduces allergic inflammation. We also determined whether 5-HTP decreases passage of leukocytes through the endothelial barrier by regulating endothelial cell function.

Abdala-Valencia, Hiam
Berdnikovs, Sergejs
McCary, Christine A.
Urick, Daniela
Mahadevia, Riti
Marchese, Michelle E.
Swartz, Kelsey
Wright, Lakiea
Mutlu, Gökhan M.
Cook-Mills, Joan M.
Publication Title: 
Acupuncture & Electro-Therapeutics Research

External gigong emitted by a quartz crystal upon application of electric current was evaluated by its biological effects, such as changes in frequency-analyzed electroencephalograms (EEG) in rabbits and spontaneous electrical activity of the rat pineal gland. Physical properties of this external gigong cannot be evaluated by currently available physical means. Three types of EEG changes were produced depending on the intensity of current applied to the crystal. These changes corresponded fairly well to the dose-dependent EEG changes after intravenous administration of 5-hydroxytryptophan.

Takeshige, C.
Aoki, T.
Publication Title: 
Japanese Journal of Pharmacology
Shimizu, T.
Fujisaki, T.
Koja, T.
Kojima, K.
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