Acarbose

Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Indian medicinal plants used in the Ayurvedic traditional system to treat diabetes are a valuable source of novel anti-diabetic agents. Pancreatic ?-amylase inhibitors offer an effective strategy to lower the levels of post-prandial hyperglycemia via control of starch breakdown. In this study, seventeen Indian medicinal plants with known hypoglycemic properties were subjected to sequential solvent extraction and tested for ?-amylase inhibition, in order to assess and evaluate their inhibitory potential on PPA (porcine pancreatic ?-amylase).

Author(s): 
P, Sudha
Zinjarde, Smita S.
Bhargava, Shobha Y.
Kumar, Ameeta R.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Indian medicinal plants used in the Ayurvedic traditional system to treat diabetes are a valuable source of novel anti-diabetic agents. Pancreatic α-amylase inhibitors offer an effective strategy to lower the levels of post-prandial hyperglycemia via control of starch breakdown. In this study, seventeen Indian medicinal plants with known hypoglycemic properties were subjected to sequential solvent extraction and tested for α-amylase inhibition, in order to assess and evaluate their inhibitory potential on PPA (porcine pancreatic α-amylase).

Author(s): 
P, Sudha
Zinjarde, Smita S.
Bhargava, Shobha Y.
Kumar, Ameeta R.
Publication Title: 
Biochemistry

An approach to controlling blood glucose levels in individuals with type 2 diabetes is to target alpha-amylases and intestinal glucosidases using alpha-glucosidase inhibitors acarbose and miglitol. One of the intestinal glucosidases targeted is the N-terminal catalytic domain of maltase-glucoamylase (ntMGAM), one of the four intestinal glycoside hydrolase 31 enzyme activities responsible for the hydrolysis of terminal starch products into glucose.

Author(s): 
Sim, Lyann
Jayakanthan, Kumarasamy
Mohan, Sankar
Nasi, Ravindranath
Johnston, Blair D.
Pinto, B. Mario
Rose, David R.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Indian medicinal plants used in the Ayurvedic traditional system to treat diabetes are a valuable source of novel anti-diabetic agents. Pancreatic α-amylase inhibitors offer an effective strategy to lower the levels of post-prandial hyperglycemia via control of starch breakdown. In this study, seventeen Indian medicinal plants with known hypoglycemic properties were subjected to sequential solvent extraction and tested for α-amylase inhibition, in order to assess and evaluate their inhibitory potential on PPA (porcine pancreatic α-amylase).

Author(s): 
P, Sudha
Zinjarde, Smita S.
Bhargava, Shobha Y.
Kumar, Ameeta R.
Publication Title: 
Bioorganic & Medicinal Chemistry

Inhibition of intestinal α-glucosidases and pancreatic α-amylases is an approach to controlling blood glucose and serum insulin levels in individuals with Type II diabetes. The two human intestinal glucosidases are maltase-glucoamylase and sucrase-isomaltase. Each incorporates two family 31 glycoside hydrolases responsible for the final step of starch hydrolysis.

Author(s): 
Jones, Kyra
Sim, Lyann
Mohan, Sankar
Kumarasamy, Jayakanthan
Liu, Hui
Avery, Stephen
Naim, Hassan Y.
Quezada-Calvillo, Roberto
Nichols, Buford L.
Pinto, B. Mario
Rose, David R.
Publication Title: 
Clinical Drug Investigation

BACKGROUND AND OBJECTIVES: The burden of type 2 diabetes mellitus is growing rapidly, particularly in the Asia-Pacific region. The aim of this international, large-scale, observational study was to investigate the efficacy and tolerability of the antidiabetic agent acarbose as add-on or monotherapy in a range of patients with type 2 diabetes, including those with cardiovascular morbidities. The majority of practices were included from high-burden regions (predominantly those in the Asia-Pacific region). METHODS: This was an observational study conducted in 15 countries/regions.

Author(s): 
Zhang, Weiwei
Kim, Dongjun
Philip, Elizabeth
Miyan, Zahid
Barykina, Irina
Schmidt, Birgit
Stein, Herbert
Gluco VIP study
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