Acid Phosphatase

Publication Title: 
Journal of Ethnopharmacology

The antiamoebic effect of a crude drug formulation against Entamoeba histolytica was studied. In the traditional system of medicine in India, the formulation has been prescribed for intestinal disorders. It comprises of five medicinal herbs, namely, Boerhavia diffusa, Berberis aristata, Tinospora cordifolia, Terminalia chebula and Zingiber officinale. The dried and pulverized plants were extracted in ethanol together and individually.

Author(s): 
Sohni, Y. R.
Kaimal, P.
Bhatt, R. M.
Publication Title: 
Reproductive Toxicology (Elmsford, N.Y.)

Toxic effects of beryllium salts on the reproductive organs of cyclic adult female albino rats have been studied. An attempt was made to overcome these effects using an Ayurvedic medicine Liv-52 (Himalaya Drug Co., Bombay). Liv-52-primed rats (1 mL/rat/day for 15 days) were exposed to beryllium nitrate intravenously and were sacrificed at different time intervals. At autopsy ovary, uterus, cervix, and vagina were processed for biochemical and histopathologic examination.

Author(s): 
Mathur, R.
Mathur, S.
Prakash, A. O.
Publication Title: 
Vascular Pharmacology

In the present study, we have investigated the efficacy of Indian ayurvedic herbal formulation Triphala on monosodium urate crystal-induced inflammation in mice; an experimental model for gouty arthritis and compared it with that of the non-steroidal anti-inflammatory drug, Indomethacin. The anti-arthritic effect of Triphala was evaluated by measuring changes in the paw volume, lysosomal enzyme activities, lipid peroxidation, anti-oxidant status and inflammatory mediator TNF-alpha in control and monosodium urate crystal-induced mice.

Author(s): 
Sabina, E. P.
Rasool, M.
Publication Title: 
The Journal of Biological Chemistry

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by bone erosion and cartilage destruction in the joints. Many of the conventional antiarthritic drugs are effective in suppressing inflammation, but they do not offer protection against bone damage. Furthermore, the prolonged use of these drugs is associated with severe adverse reactions. Thus, new therapeutic agents that can control both inflammation and bone damage but with minimal side effects are sought.

Author(s): 
Nanjundaiah, Siddaraju M.
Venkatesha, Shivaprasad H.
Yu, Hua
Tong, Li
Stains, Joseph P.
Moudgil, Kamal D.
Publication Title: 
The New England Journal of Medicine

To compare the clinical usefulness of the serum markers prostate-specific antigen (PSA) and prostatic acid phosphatase (PAP), we measured them by radioimmunoassay in 2200 serum samples from 699 patients, 378 of whom had prostatic cancer. PSA was elevated in 122 of 127 patients with newly diagnosed, untreated prostatic cancer, including 7 of 12 patients with unsuspected early disease and all of 115 with more advanced disease. The PSA level increased with advancing clinical stage and was proportional to the estimated volume of the tumor.

Author(s): 
Stamey, T. A.
Yang, N.
Hay, A. R.
McNeal, J. E.
Freiha, F. S.
Redwine, E.
Publication Title: 
World journal of gastroenterology: WJG

AIM: To develop a Brown Norway (BN) rat model to determine the potential allergenicity of novel proteins in genetically modified food. METHODS: The allergenicity of different proteins were compared, including ovalbumin (OVA), a potent respiratory and food allergen, bovine serum albumin (BSA), a protein that is considered to have a lesser allergenic potential, and potato acid phosphatase (PAP), a non-allergenic protein when administered to BN rats via different routes of exposure (intraperitoneally or by gavage). IgG and IgE antibody responses were determined by ELISA and PCA, respectively.

Author(s): 
Jia, Xu-Dong
Li, Ning
Wu, Yong-Ning
Yang, Xiao-Guang
Publication Title: 
The Journal of Biological Chemistry

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by bone erosion and cartilage destruction in the joints. Many of the conventional antiarthritic drugs are effective in suppressing inflammation, but they do not offer protection against bone damage. Furthermore, the prolonged use of these drugs is associated with severe adverse reactions. Thus, new therapeutic agents that can control both inflammation and bone damage but with minimal side effects are sought.

Author(s): 
Nanjundaiah, Siddaraju M.
Venkatesha, Shivaprasad H.
Yu, Hua
Tong, Li
Stains, Joseph P.
Moudgil, Kamal D.
Publication Title: 
Biological & Pharmaceutical Bulletin

Honokiol, a neolignan, is a physiologically active component of kouboku (Magnolia obovata), a herb used in traditional Chinese medicine. This study investigated the effects of honokiol on the differentiation and function of osteoclasts induced by receptor activator of nuclear factor-kappaB ligand (RANKL). Honokiol markedly inhibited RANKL-induced tartrate-resistant acid phosphatase (TRAP) activity and the formation of TRAP-positive multinucleated cells in both bone marrow-derived monocytes and RAW264 cells.

Author(s): 
Hasegawa, Shin-Ichi
Yonezawa, Takayuki
Ahn, Jae-Yong
Cha, Byung-Yoon
Teruya, Toshiaki
Takami, Masamichi
Yagasaki, Kazumi
Nagai, Kazuo
Woo, Je-Tae
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