Activin Receptors, Type I

Publication Title: 
The Journal of Biological Chemistry

Mesenchymal stem cells (MSCs) are bone marrow stromal cells that can differentiate into multiple lineages. We previously demonstrated that BMP9 is one of the most potent BMPs to induce osteogenic differentiation of MSCs. BMP9 is one of the least studied BMPs. Whereas ALK1, ALK5, and/or endoglin have recently been reported as potential BMP9 type I receptors in endothelial cells, little is known about type I receptor involvement in BMP9-induced osteogenic differentiation in MSCs.

Author(s): 
Luo, Jinyong
Tang, Min
Huang, Jiayi
He, Bai-Cheng
Gao, Jian-Li
Chen, Liang
Zuo, Guo-Wei
Zhang, Wenli
Luo, Qing
Shi, Qiong
Zhang, Bing-Qiang
Bi, Yang
Luo, Xiaoji
Jiang, Wei
Su, Yuxi
Shen, Jikun
Kim, Stephanie H.
Huang, Enyi
Gao, Yanhong
Zhou, Jian-Zhong
Yang, Ke
Luu, Hue H.
Pan, Xiaochuan
Haydon, Rex C.
Deng, Zhong-Liang
He, Tong-Chuan
Publication Title: 
American Journal of Respiratory and Critical Care Medicine

RATIONALE: Because acute lung injury is a sporadic disease produced by heterogeneous precipitating factors, previous genetic analyses are mainly limited to candidate gene case-control studies. OBJECTIVES: To develop a genome-wide strategy in which single nucleotide polymorphism associations are assessed for functional consequences to survival during acute lung injury in mice. METHODS: To identify genes associated with acute lung injury, 40 inbred strains were exposed to acrolein and haplotype association mapping, microarray, and DNA-protein binding were assessed.

Author(s): 
Leikauf, George D.
Concel, Vincent J.
Liu, Pengyuan
Bein, Kiflai
Berndt, Annerose
Ganguly, Koustav
Jang, An Soo
Brant, Kelly A.
Dietsch, Maggie
Pope-Varsalona, Hannah
Dopico, Richard A.
Di, Y. P. Peter
Li, Qian
Vuga, Louis J.
Medvedovic, Mario
Kaminski, Naftali
You, Ming
Prows, Daniel R.
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