Acute-Phase Proteins

Publication Title: 
Nephrology, Dialysis, Transplantation: Official Publication of the European Dialysis and Transplant Association - European Renal Association

BACKGROUND: Inflammation is commonly associated with malnutrition and cardiovascular disease in end-stage renal failure patients. Anti-inflammatory properties of the isoflavones, a micronutrient component of soy, have been reported in several experimental models and disease conditions, but never in renal failure. We hypothesized that dietary soy isoflavones correct laboratory evidence of systemic inflammation in haemodialysis (HD) patients with underlying high blood levels of C-reactive protein (CRP).

Author(s): 
Fanti, Paolo
Asmis, Reto
Stephenson, Tammy J.
Sawaya, B. Peter
Franke, Adrian A.
Publication Title: 
Arthritis and Rheumatism

OBJECTIVE: Expression of matrix metalloproteinase 9 (MMP-9) is up-regulated in osteoarthritis (OA) and usually presents as multiple bands when synovial fluid (SF) from OA patients is analyzed by zymography. Among these bands is an approximately 125-130-kd band for high molecular weight (HMW) gelatinase, which has not been characterized. This study was undertaken to characterize the HMW MMP activity in OA SF. METHODS: MMP activity in OA SF was determined by gelatin zymography. Recombinant MMPs were used to identify MMP activity on the zymogram.

Author(s): 
Gupta, Kalpana
Shukla, Meenakshi
Cowland, Jack B.
Malemud, Charles J.
Haqqi, Tariq M.
Publication Title: 
Menopause (New York, N.Y.)

OBJECTIVE: C-reactive protein and fibrinogen are established atherosclerotic cardiovascular disease risk factors. These acute-phase proteins and the proinflammatory cytokines tumor necrosis factor alpha, interleukin-6, and interleukin-1beta may be elevated in obesity and with menopause. The purpose of this multicenter study was to identify whether centrally located fat and/or overall adiposity were related to these inflammatory markers in healthy postmenopausal women.

Author(s): 
Perry, Courtney D.
Alekel, D. Lee
Ritland, Laura M.
Bhupathiraju, Shilpa N.
Stewart, Jeanne W.
Hanson, Laura N.
Matvienko, Oksana A.
Kohut, Marian L.
Reddy, Manju B.
Van Loan, Marta D.
Genschel, Ulrike
Publication Title: 
Clinical journal of the American Society of Nephrology: CJASN

BACKGROUND: Because of the risk of performing renal biopsies in children with co-morbid conditions, we carried out this study to identify candidate protein biomarkers in the urine of HIV-infected children with renal disease. DESIGN, SETTING, PARTICIPANTS & MEASUREMENTS: Urine samples from HIV-infected children with biopsy proven HIV-nephropathy (HIVAN; n = 4), HIV-associated Hemolytic Uremic Syndrome (HIV-HUS; n = 2), or no renal disease (n = 3) were analyzed by two-dimensional electrophoresis (2-DE) and proteomic methods.

Author(s): 
Soler-García, Angel A.
Johnson, Douglas
Hathout, Yetrib
Ray, Patricio E.
Publication Title: 
PloS One

BACKGROUND: A liver-derived protein, fetuin-A, was first purified from calf fetal serum in 1944, but its potential role in lethal systemic inflammation was previously unknown. This study aims to delineate the molecular mechanisms underlying the regulation of hepatic fetuin-A expression during lethal systemic inflammation (LSI), and investigated whether alterations of fetuin-A levels affect animal survival, and influence systemic accumulation of a late mediator, HMGB1.

Author(s): 
Li, Wei
Zhu, Shu
Li, Jianhua
Huang, Yan
Zhou, Rongrong
Fan, Xuegong
Yang, Huan
Gong, Xing
Eissa, N. Tony
Jahnen-Dechent, Willi
Wang, Ping
Tracey, Kevin J.
Sama, Andrew E.
Wang, Haichao
Publication Title: 
Current Molecular Medicine

Infection and injury are two seemingly unrelated processes that often converge on common innate inflammatory responses mediated by pathogen- or damage-associated molecular patterns (PAMPs or DAMPs). If dysregulated, an excessive inflammation manifested by the overproduction and release of proinflammatory mediators (e.g., TNF, IFN-γ, and HMGB1) may adversely lead to many pathogenic consequences.

Author(s): 
Wang, H.
Sama, A. E.
Publication Title: 
Bioscience, Biotechnology, and Biochemistry

Anoectochilus formosanus is used in traditional folk medicine as an hepatoprotective agent. The purpose of this study was to investigate the effects of a standardized aqueous extract of A. formosanus (SAEAF) on thioacetamide (TAA)-induced liver fibrosis. An in vitro study showed that the inhibitive effect of kinsenoside, a major component of SAEAF, on tumor necrosis factor alpha (TNF-alpha) secretion from Kupffer cells might be derived at least partly from downregulation of LPS-receptor Toll-like receptor 4 (TLR4) signaling.

Author(s): 
Wu, Jin-Bin
Chuang, Hin-Ru
Yang, Li-Chan
Lin, Wen-Chuan
Publication Title: 
Journal of Periodontal Research

BACKGROUND AND OBJECTIVE: Dietary manipulation, including caloric restriction, has been shown to impact host response capabilities significantly, particularly in association with aging. This investigation compared systemic inflammatory and immune-response molecules in rhesus monkeys (Macaca mulatta). MATERIAL AND METHODS: Monkeys on continuous long-term calorie-restricted diets and a matched group of animals on a control ad libitum diet, were examined for systemic response profiles including the effects of both gender and aging.

Author(s): 
Ebersole, J. L.
Steffen, M. J.
Reynolds, M. A.
Branch-Mays, G. L.
Dawson, D. R.
Novak, K. F.
Gunsolley, J. C.
Mattison, J. A.
Ingram, D. K.
Novak, M. J.
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