Administration, Intravaginal

Publication Title: 
American Family Physician

The results of large clinical trials have led physicians and patients to question the safety of hormone therapy for menopause. In the past, physicians prescribed hormone therapy to improve overall health and prevent cardiac disease, as well as for symptoms of menopause. Combined estrogen/progestogen therapy, but not estrogen alone, increases the risk of breast cancer when used for more than three to five years.

Author(s): 
Hill, D. Ashley
Crider, Mark
Hill, Susan R.
Publication Title: 
American Family Physician

The results of large clinical trials have led physicians and patients to question the safety of hormone therapy for menopause. In the past, physicians prescribed hormone therapy to improve overall health and prevent cardiac disease, as well as for symptoms of menopause. Combined estrogen/progestogen therapy, but not estrogen alone, increases the risk of breast cancer when used for more than three to five years.

Author(s): 
Hill, D. Ashley
Crider, Mark
Hill, Susan R.
Publication Title: 
American Family Physician

The results of large clinical trials have led physicians and patients to question the safety of hormone therapy for menopause. In the past, physicians prescribed hormone therapy to improve overall health and prevent cardiac disease, as well as for symptoms of menopause. Combined estrogen/progestogen therapy, but not estrogen alone, increases the risk of breast cancer when used for more than three to five years.

Author(s): 
Hill, D. Ashley
Crider, Mark
Hill, Susan R.
Publication Title: 
Journal of the Royal Society of Health
Author(s): 
Lis-Balchin, M.
Publication Title: 
Infectious Diseases in Obstetrics and Gynecology

OBJECTIVE: To evaluate the safety of the antimicrobial peptide, lactocin 160. METHODS: Lactocin 160, a product of vaginal probiotic Lactobacillus rhamnosus 160 was evaluated for toxicity and irritation. An in vitro human organotypic vaginal-ectocervical tissue model (EpiVaginal) was employed for the safety testing by determining the exposure time to reduce tissue viability to 50% (ET-50). Hemolytic activity of lactocin160 was tested using 8% of human erythrocyte suspension. Susceptibility of lactobacilli to lactocin160 was also studied.

Author(s): 
Dover, Sara E.
Aroutcheva, Alla A.
Faro, S.
Chikindas, Michael L.
Publication Title: 
Infectious Diseases in Obstetrics and Gynecology

Bacterial vaginosis (BV), a condition affecting millions of women each year, is primarily caused by the gram-variable organism Gardnerella vaginalis. A number of organisms associated with BV cases have been reported to develop multidrug resistance, leading to the need for alternative therapies. Previously, we reported the antimicrobial peptide subtilosin has proven antimicrobial activity against G. vaginalis, but not against the tested healthy vaginal microbiota of lactobacilli.

Author(s): 
Sutyak, Katia E.
Anderson, Robert A.
Dover, Sara E.
Feathergill, Kenneth A.
Aroutcheva, Alla A.
Faro, Sebastian
Chikindas, Michael L.
Publication Title: 
BMC pregnancy and childbirth

BACKGROUND: Rates of labour induction are increasing. We conducted this systematic review to assess the evidence supporting use of each method of labour induction. METHODS: We listed methods of labour induction then reviewed the evidence supporting each.

Author(s): 
Mozurkewich, Ellen L.
Chilimigras, Julie L.
Berman, Deborah R.
Perni, Uma C.
Romero, Vivian C.
King, Valerie J.
Keeton, Kristie L.
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