Adrenergic alpha-2 Receptor Antagonists

Publication Title: 
PloS One

Acute stress affects cellular integrity in many tissues including the liver, but its underlying mechanism is still unclear. The aim of the present study was to investigate the potential involvement of catecholamines and adrenoceptors in the regulation of acute restraint stress-induced liver injury. Restraint was achieved by placing mice in restraint tubes.

Author(s): 
Zhu, Qing
Gu, Liwei
Wang, Yimei
Jia, Li
Zhao, Zengming
Peng, Shuangqing
Lei, Linsheng
Publication Title: 
British Journal of Anaesthesia

BACKGROUND: Although acupuncture analgesia is well documented, its mechanisms have not been thoroughly clarified. We previously showed that electroacupuncture (EA) activates supraspinal serotonin- and norepinephrine-containing neurones that project to the spinal cord. This study investigates the involvement of spinal alpha(2)-adrenoceptors (α2-ARs) and 5-hydroxytryptamine (serotonin) receptors (5-HTRs) in EA effects on an inflammatory pain rat model.

Author(s): 
Zhang, Y.
Zhang, R. X.
Zhang, M.
Shen, X. Y.
Li, A.
Xin, J.
Ren, K.
Berman, B. M.
Tan, M.
Lao, L.
Publication Title: 
British Journal of Anaesthesia

BACKGROUND: Although acupuncture analgesia is well documented, its mechanisms have not been thoroughly clarified. We previously showed that electroacupuncture (EA) activates supraspinal serotonin- and norepinephrine-containing neurones that project to the spinal cord. This study investigates the involvement of spinal alpha(2)-adrenoceptors (α2-ARs) and 5-hydroxytryptamine (serotonin) receptors (5-HTRs) in EA effects on an inflammatory pain rat model.

Author(s): 
Zhang, Y.
Zhang, R. X.
Zhang, M.
Shen, X. Y.
Li, A.
Xin, J.
Ren, K.
Berman, B. M.
Tan, M.
Lao, L.
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