Adrenergic beta-1 Receptor Antagonists

Publication Title: 
Brain Research

Labetalol, a combined alpha1, beta1, and beta2 adrenoceptor-blocking drug, has been shown to have analgesic properties in vivo. To determine the underlying mechanisms, we examined its effects on GABAA receptor-mediated spontaneous inhibitory postsynaptic currents (sIPSCs) and spontaneous firings of rat ventrolateral periaqueductal gray (PAG) neurons, either mechanically dissociated, or in acute brain slices. These PAG neurons mediate opioid-mediated analgesia and pain transmission and are under tonic control of GABAergic interneurons.

Author(s): 
Xiao, Cheng
Zhou, Chunyi
Atlas, Glen
Delphin, Ellise
Ye, Jiang Hong
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