Adrenergic beta-Agonists

Publication Title: 
Indian Journal of Experimental Biology

Cardioprotective effect of ethanolic extract of Terminalia chebula fruits (500 mg/kg body wt) was examined in isoproterenol (200 mg/kg body wt) induced myocardial damage in rats. In isoproterenol administered rats, the level of lipid peroxides increased significantly in the serum and heart. A significant decrease was observed in the activity of the myocardial marker enzymes with a concomitant increase in their activity in serum. Histopathological examination was carried out to confirm the myocardial necrosis. T.

Author(s): 
Suchalatha, S.
Shyamala Devi, C. S.
Publication Title: 
Thorax

BACKGROUND: Patients with asthma are interested in the use of breathing exercises but their role is uncertain. The effects of the Buteyko breathing technique, a device which mimics pranayama (a yoga breathing technique), and a dummy pranayama device on bronchial responsiveness and symptoms were compared over 6 months in a parallel group study. METHODS: Ninety patients with asthma taking an inhaled corticosteroid were randomised after a 2 week run in period to Eucapnic Buteyko breathing, use of a Pink City Lung Exerciser (PCLE) to mimic pranayama, or a PCLE placebo device.

Author(s): 
Cooper, S.
Oborne, J.
Newton, S.
Harrison, V.
Thompson Coon, J.
Lewis, S.
Tattersfield, A.
Publication Title: 
Journal of Cardiovascular Pharmacology

Cardiac hypertrophy occurs in response to increased workload, such as hypertension or valvular heart disease. Oxidative stress has been implicated in cardiac hypertrophy and in its transition to heart failure. This study was taken up with the objective to evaluate the role of oxidative stress in cardiomyoblast hypertrophy and its modulation by Desmodium gangeticum (DG) that has been traditionally used in Ayurveda, an Indian system of medicine. The methanolic root extract was analyzed for total phenolic content and tested for antioxidant potential.

Author(s): 
Sankar, Vandana
Pangayarselvi, Balasubramaniam
Prathapan, Ayyappan
Raghu, Kozhiparambil Gopalan
Publication Title: 
The Journal of Asthma: Official Journal of the Association for the Care of Asthma

One approach to address asthma disparities has been to create evidence-based guidelines to standardize asthma care and education. However, the adoption of these recommendations has been suboptimal among many providers. As a result, low-income minority patients may not be receiving adequate instruction in asthma self-management. In addition, these patients may fail to follow guideline-based recommendations. We conducted 25 interviews to identify the extent to which urban low-income adults have received training in, and implement, self-management protocols for acute asthma.

Author(s): 
George, Maureen
Campbell, Jacquelyn
Rand, Cynthia
Publication Title: 
BMJ (Clinical research ed.)

OBJECTIVE: To determine if earlier administration of epinephrine (adrenaline) in patients with non-shockable cardiac arrest rhythms is associated with increased return of spontaneous circulation, survival, and neurologically intact survival. DESIGN: Post hoc analysis of prospectively collected data in a large multicenter registry of in-hospital cardiac arrests (Get With The Guidelines-Resuscitation). SETTING: We utilized the Get With The Guidelines-Resuscitation database (formerly National Registry of Cardiopulmonary Resuscitation, NRCPR).

Author(s): 
Donnino, Michael W.
Salciccioli, Justin D.
Howell, Michael D.
Cocchi, Michael N.
Giberson, Brandon
Berg, Katherine
Gautam, Shiva
Callaway, Clifton
American Heart Association’s Get With The Guidelines-Resuscitation Investigators
Publication Title: 
Thorax

BACKGROUND: Patients with asthma are interested in the use of breathing exercises but their role is uncertain. The effects of the Buteyko breathing technique, a device which mimics pranayama (a yoga breathing technique), and a dummy pranayama device on bronchial responsiveness and symptoms were compared over 6 months in a parallel group study. METHODS: Ninety patients with asthma taking an inhaled corticosteroid were randomised after a 2 week run in period to Eucapnic Buteyko breathing, use of a Pink City Lung Exerciser (PCLE) to mimic pranayama, or a PCLE placebo device.

Author(s): 
Cooper, S.
Oborne, J.
Newton, S.
Harrison, V.
Thompson Coon, J.
Lewis, S.
Tattersfield, A.
Publication Title: 
Arteriosclerosis, Thrombosis, and Vascular Biology

OBJECTIVE: Plasma lipoprotein levels are determined by the balance between lipoprotein production and clearance. Recently, angiopoietin-like protein 4 (ANGPTL4) was uncovered as a novel endocrine factor that potently raises plasma triglyceride levels by inhibiting triglyceride clearance. However, very little is known about ANGPTL4 in human. Here we set out to identify physiological determinants of plasma ANGPTL4 levels in humans, focusing on the effect of energy restriction and plasma FFAs. METHODS AND RESULTS: We developed an ELISA for quantitative measurement of ANGPTL4 in human plasma.

Author(s): 
Kersten, Sander
Lichtenstein, Laeticia
Steenbergen, Emma
Mudde, Karin
Hendriks, Henk F. J.
Hesselink, Matthijs K.
Schrauwen, Patrick
Müller, Michael
Publication Title: 
Aging Cell

Insulin sensitivity deteriorates with age, but mechanisms remain unclear. Age-related changes in the function of subcutaneous white adipose tissue (sWAT) are less characterized than those in visceral WAT. We hypothesized that metabolic alterations in sWAT, which in contrast to epididymal WAT, harbors a subpopulation of energy-dissipating UCP1+ brown adipocytes, promote age-dependent progression toward insulin resistance. Indeed, we show that a predominant consequence of aging in murine sWAT is loss of 'browning'.

Author(s): 
Rogers, Nicole H.
Landa, Alejandro
Park, Seongjoon
Smith, Roy G.
Publication Title: 
Acta Pharmacologica Sinica

AIM: To investigate the anti-asthmatic mechanisms of the traditional Chinese medicine Pericarpium citri reticulatae (PCR). METHODS: The alkaloid section (AS) of PCR was extracted using an ion exchange resin, separated, and purified into different fractions by semi-preparative HPLC. These fractions were screened for beta2-adrenergic receptor (beta(2)AR) agonistic activity using rat beta(2)AR-transfected CHO-CRE-EGFP cells.

Author(s): 
Shi, Qian
Liu, Ze
Yang, Yang
Geng, Peng
Zhu, Yuan-yuan
Zhang, Qi
Bai, Fang
Bai, Gang
Publication Title: 
Japanese Journal of Pharmacology

Methoxamine, isoprenaline, salbutamol and dobutamine were used to inhibit the spontaneous contraction of various rabbit small and large intestinal sections. From the concentration of the drugs that produced a similar magnitude of inhibition of the spontaneous contraction, the following deductions were made: The small intestine compared to the large intestine responded more to methoxamine, indicating a predominant presence of alpha receptors in the small intestine. The reverse is true for isoprenaline, indicating a predominant presence of beta receptors in the large intestine.

Author(s): 
Sim, M. K.
Lim, J. M.
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