Adult Stem Cells

Publication Title: 
Folia Histochemica Et Cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society

The insulin-like growth factor-2 (Igf2)-H19 locus encodes important paternally imprinted genes that govern normal embryonic development. While Igf-2 encodes IGF2, which is an autocrine/paracrine mitogen,† transcription of H19 gives rise to non-coding mRNA that is a precursor of several microRNAs (miRNAs) that negatively affect cell proliferation.

Author(s): 
Ratajczak, Mariusz Z.
Publication Title: 
Cell Metabolism

Abnormal splicing of LMNA gene or aberrant processing of prelamin A results in progeroid syndrome. Here we show that lamin A interacts with and activates SIRT1. SIRT1 exhibits reduced association with nuclear matrix (NM) and decreased deacetylase activity in the presence of progerin or prelamin A,†leading to rapid depletion of adult stem cells (ASCs) in Zmpste24(-/-) mice. Resveratrol enhances the binding between SIRT1 and A-type lamins to increases its deacetylase activity.

Author(s): 
Liu, Baohua
Ghosh, Shrestha
Yang, Xi
Zheng, Huiling
Liu, Xinguang
Wang, Zimei
Jin, Guoxiang
Zheng, Bojian
Kennedy, Brian K.
Suh, Yousin
Kaeberlein, Matt
Tryggvason, Karl
Zhou, Zhongjun
Publication Title: 
Nature

Schistosomiasis is among the most prevalent human parasitic diseases, affecting more than 200 million people worldwide. The aetiological agents of this disease are trematode flatworms (Schistosoma) that live and lay eggs within the vasculature of the host. These eggs lodge in host tissues, causing inflammatory responses that are the primary cause of morbidity. Because these parasites can live and reproduce within human hosts for decades, elucidating the mechanisms that promote their longevity is of fundamental importance.

Author(s): 
Collins, James J.
Wang, Bo
Lambrus, Bramwell G.
Tharp, Marla E.
Iyer, Harini
Newmark, Phillip A.
Publication Title: 
Aging

The Editorial Board of Aging reviews research papers published in 2009, which they believe have or will have significant impact on aging research. Among many others, the topics include genes that accelerate aging or in contrast promote longevity in model organisms, DNA damage responses and telomeres, molecular mechanisms of life span extension by calorie restriction and pharmacological interventions into aging.

Author(s): 
Blagosklonny, Mikhail V.
Campisi, Judy
Sinclair, David A.
Bartke, Andrzej
Blasco, Maria A.
Bonner, William M.
Bohr, Vilhelm A.
Brosh, Robert M.
Brunet, Anne
DePinho, Ronald A.
Donehower, Lawrence A.
Finch, Caleb E.
Finkel, Toren
Gorospe, Myriam
Gudkov, Andrei V.
Hall, Michael N.
Hekimi, Siegfried
Helfand, Stephen L.
Karlseder, Jan
Kenyon, Cynthia
Kroemer, Guido
Longo, Valter
Nussenzweig, Andre
Osiewacz, Heinz D.
Peeper, Daniel S.
Rando, Thomas A.
Rudolph, K. Lenhard
Sassone-Corsi, Paolo
Serrano, Manuel
Sharpless, Norman E.
Skulachev, Vladimir P.
Tilly, Jonathan L.
Tower, John
Verdin, Eric
Vijg, Jan
Publication Title: 
Stem Cells and Development

We have previously demonstrated that hypoxia stimulates adipose-derived stem cells (ASCs) through the generation of reactive oxygen species (ROS). However, the precise mechanism involved in the ROS generation by ASCs is not well understood. We sought to investigate in this work: (1) which subtype of NADPH oxidase (Nox) is primarily expressed in ASCs; (2) where Nox4 is localized in ASCs; and (3) whether silencing of Nox4 attenuates hypoxia-enhanced function of ASC.

Author(s): 
Kim, Ji Hye
Song, Seung-Yong
Park, Sang Gyu
Song, Sun U.
Xia, Ying
Sung, Jong-Hyuk
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