Alcoholic Intoxication

Publication Title: 
Criminal behaviour and mental health: CBMH

BACKGROUND: Alcohol-related violence is of major concern to society. Around half of all violent crimes are alcohol related, and yet interventions for alcohol-related violence are under-developed. Often, offenders receive treatment for substance use or violence, but not the two in nexus. AIM: My aim was to conduct a Rapid Evidence Assessment of interventions with a focus on treating established nonsexual violence in the context of alcohol use, to describe the content of these interventions, where they take place and their effectiveness in reducing alcohol problems and/or violence.

Author(s): 
McMurran, Mary
Publication Title: 
Der Nervenarzt
Author(s): 
Hubach, H.
Publication Title: 
British Journal of Pharmacology and Chemotherapy

Seven structurally-related compounds consisting of three antidepressant drugs (imipramine, desmethylimipramine and amitriptyline), three tranquillizing agents (promazine, chlorpromazine and chlorprothixene) and a hybrid, desmethylpromazine, have been examined in a series of tests involving autonomic functions and antagonism of reserpine.

Author(s): 
Halliwell, G.
Quinton, R. M.
Williams, F. E.
Publication Title: 
Life Sciences

The ability of adenosine to modify the CNS effects of acute and chronic ethanol was studied by using theophylline, an adenosine antagonist, and dipyridamole, a blocker of adenosine reuptake. We also studied the binding characteristics of adenosine using crude membranes of whole brain. Theophylline pretreatment prior to acute ethanol administration markedly reduced the duration of ethanol-induced sleep and similarly decreased the intensity and duration of motor incoordination.

Author(s): 
Dar, M. S.
Mustafa, S. J.
Wooles, W. R.
Publication Title: 
The International Journal of Clinical and Experimental Hypnosis
Author(s): 
Venn, J.
Publication Title: 
Alcoholism, Clinical and Experimental Research

BACKGROUND: The glutamate system plays a major role in mediating EtOH's effects on brain and behavior, and is implicated in the pathophysiology of alcohol-related disorders. N-methyl-D-aspartate receptor (NMDAR) antagonists such as MK-801 (dizocilpine) interact with EtOH at the behavioral level, but the molecular basis of this interaction is unclear. METHODS: We first characterized the effects of MK-801 treatment on responses to the ataxic (accelerating rotarod), hypothermic and sedative/hypnotic effects of acute EtOH administration in C57BL/6J and 129/SvImJ inbred mice.

Author(s): 
Palachick, Benjamin
Chen, Yi-Chyan
Enoch, Abigail J.
Karlsson, Rose-Marie
Mishina, Masayoshi
Holmes, Andrew
Publication Title: 
Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology

Compounds with anti-glutamatergic properties currently in clinical use for various indications (eg Alzheimer's disease, epilepsy, psychosis, mood disorders) have potential utility as novel treatments for alcoholism. Enhanced sensitivity to certain acute intoxicating effects (ataxia, sedative) of alcohol may be one mechanism by which anti-glutamatergic drugs modulate alcohol use.

Author(s): 
Chen, Yi-Chyan
Holmes, Andrew
Publication Title: 
Addiction Biology

The synaptic signaling mechanisms mediating the behavioral effects of ethanol (EtOH) remain poorly understood. Post-synaptic density 95 (PSD-95, SAP-90, Dlg4) is a key orchestrator of N-methyl-D-aspartate receptors (NMDAR) and glutamatergic synapses, which are known to be major sites of EtOH's behavioral actions. However, the potential contribution of PSD-95 to EtOH-related behaviors has not been established.

Author(s): 
Camp, Marguerite C.
Feyder, Michael
Ihne, Jessica
Palachick, Benjamin
Hurd, Benita
Karlsson, Rose-Marie
Noronha, Bianca
Chen, Yi-Chyan
Coba, Marcelo P.
Grant, Seth G. N.
Holmes, Andrew
Publication Title: 
Alcoholism, Clinical and Experimental Research

BACKGROUND: Initial sensitivity to ethanol (EtOH) and the capacity to develop acute functional tolerance (AFT) to its adverse effects may influence the amount of alcohol consumed and may also predict future alcohol use patterns. The current study assessed sensitivity and AFT to the ataxic and hypnotic effects of EtOH in the first replicate of mice (HDID-1) selectively bred for high blood EtOH concentrations (BECs) following limited access to EtOH in the Drinking in the Dark (DID) paradigm.

Author(s): 
Fritz, Brandon M.
Cordero, Kristy A.
Barkley-Levenson, Amanda M.
Metten, Pamela
Crabbe, John C.
Boehm, Stephen L.
Publication Title: 
Food & Function

The present study aimed to evaluate the effect of an oral administration of marine collagen peptides (MCPs) pre- and post-acute ethanol intoxication in female Sprague-Dawley (SD) rats. MCPs were orally administered to rats at doses of 0 g per kg bw, 2.25 g per kg bw, 4.5 g per kg bw and 9.0 g per kg bw, prior to or after the oral administration of ethanol.

Author(s): 
Liang, Jiang
Li, Qiong
Lin, Bing
Yu, Yongchao
Ding, Ye
Dai, Xiaoqian
Li, Yong

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