Alkyl and Aryl Transferases

Publication Title: 
Journal of Genetics and Genomics = Yi Chuan Xue Bao

CoQ is an essential electron carrier in the mitochondrial respiratory chain of both eukaryotes and prokaryotes. It consists of a benzoquinone head group and a hydrophobic polyisoprenoid tail. The genes (COQ1-9) involved in CoQ biosynthesis have been characterized in yeast. In this study, we generated and molecularly characterized a mutant allele of a novel Drosophila gene, sbo, which encodes a protein that is predicted to catalyze the prenylation of p-hydroxybenzoate with the isoprenoid chain during the process of CoQ synthesis.

Author(s): 
Liu, Jiyong
Wu, Qinghua
He, Dianlu
Ma, Tengyu
Du, Li
Dui, Wen
Guo, Xiaoyan
Jiao, Renjie
Publication Title: 
BMC plant biology

BACKGROUND: Recently, Artemisia annua L. (annual or sweet wormwood) has received increasing attention due to the fact that the plant produces the sesquiterpenoid endoperoxide artemisinin, which today is widely used for treatment of malaria. The plant produces relatively small amounts of artemisinin and a worldwide shortage of the drug has led to intense research in order to increase the yield of artemisinin.

Author(s): 
Olofsson, Linda
Engström, Alexander
Lundgren, Anneli
Brodelius, Peter E.
Publication Title: 
International Journal of Molecular Sciences

Thapsia laciniata Rouy (Apiaceae) produces irregular and regular sesquiterpenoids with thapsane and guaiene carbon skeletons, as found in other Apiaceae species. A transcriptomic analysis utilizing Illumina next-generation sequencing enabled the identification of novel genes involved in the biosynthesis of terpenoids in Thapsia. From 66.78 million HQ paired-end reads obtained from T. laciniata roots, 64.58 million were assembled into 76,565 contigs (N50: 1261 bp). Seventeen contigs were annotated as terpene synthases and five of these were predicted to be sesquiterpene synthases.

Author(s): 
Drew, Damian Paul
Dueholm, Bjørn
Weitzel, Corinna
Zhang, Ye
Sensen, Christoph W.
Simonsen, Henrik Toft
Publication Title: 
Journal of Neuroimmune Pharmacology: The Official Journal of the Society on NeuroImmune Pharmacology

DJ-1 (PARK7) is a neuroprotective protein that protects cells from oxidative stress. Accordingly, loss-of-function DJ-1 mutations have been linked with a familial form of early onset Parkinson disease. Mechanisms by which DJ-1 level could be enriched in the CNS are poorly understood. Recently we have discovered anti-inflammatory activity of sodium benzoate (NaB), a metabolite of cinnamon and a widely-used food additive.

Author(s): 
Khasnavis, Saurabh
Pahan, Kalipada
Publication Title: 
Journal of Agricultural and Food Chemistry

Consumption of tomato products has been associated with decreased risks of chronic diseases such as cardiovascular disease and cancer, and therefore the biological functions of tomato carotenoids such as lycopene, phytoene, and phytofluene are being investigated. To study the absorption, distribution, metabolism, and excretion of these carotenoids, a bioengineered Escherichia coli model was evaluated for laboratory-scale production of stable isotope-labeled carotenoids.

Author(s): 
Lu, Chi-Hua
Choi, Jin-Ho
Engelmann Moran, Nancy
Jin, Yong-Su
Erdman, John W.
Publication Title: 
Disease Models & Mechanisms

Coenzyme Q (CoQ) or ubiquinone is a lipid component of the electron transport chain required for ATP generation in mitochondria. Mutations in CoQ biosynthetic genes are associated with rare but severe infantile multisystemic diseases. CoQ itself is a popular over-the-counter dietary supplement that some clinical and rodent studies suggest might be beneficial for neurodegenerative diseases. Here, we identify mutations in the Drosophila qless gene, which encodes an orthologue of the human PDSS1 prenyl transferase that synthesizes the isoprenoid side chain of CoQ.

Author(s): 
Grant, Jennifer
Saldanha, José W.
Gould, Alex P.
Publication Title: 
Disease Models & Mechanisms

Coenzyme Q (CoQ) or ubiquinone is a lipid component of the electron transport chain required for ATP generation in mitochondria. Mutations in CoQ biosynthetic genes are associated with rare but severe infantile multisystemic diseases. CoQ itself is a popular over-the-counter dietary supplement that some clinical and rodent studies suggest might be beneficial for neurodegenerative diseases. Here, we identify mutations in the Drosophila qless gene, which encodes an orthologue of the human PDSS1 prenyl transferase that synthesizes the isoprenoid side chain of CoQ.

Author(s): 
Grant, Jennifer
Saldanha, José W.
Gould, Alex P.
Publication Title: 
PloS One

Salvia miltiorrhiza Bunge, a perennial plant of Lamiaceae, accumulates abietane-type diterpenoids of tanshinones in root, which have been used as traditional Chinese medicine to treat neuroasthenic insomnia and cardiovascular diseases. However, to date the biosynthetic pathway of tanshinones is only partially elucidated and the mechanism for their root-specific accumulation remains unknown. To identify enzymes and transcriptional regulators involved in the biosynthesis of tanshinones, we conducted transcriptome profiling of S.

Author(s): 
Yang, Lei
Ding, Guohui
Lin, Haiyan
Cheng, Haining
Kong, Yu
Wei, Yukun
Fang, Xin
Liu, Renyi
Wang, Lingiian
Chen, Xiaoya
Yang, Changqing
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