Alloxan

Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: The leaf juice or water decoction of Catharanthus roseus L. (Apocyanaceae) is used as a folk medicine for the treatment of diabetes all over the world. In the present investigation, the leaf juice of C. roseus has been evaluated for its hypoglycemic activity in normal and alloxan-induced diabetic rabbits. METHODS: The blood glucose lowering activity of the leaf juice was studied in normal and alloxan-induced (100 mg/kg, i.v.) diabetic rabbits, after oral administration at doses of 0.5, 0.75 and 1.0 ml/kg body weight.

Author(s): 
Nammi, Srinivas
Boini, Murthy K.
Lodagala, Srinivas D.
Behara, Ravindra Babu S.
Publication Title: 
Journal of Ethnopharmacology

We undertook the present study to evaluate the hypolipidaemic effect of an aqueous extract of Tinospora cordifolia roots, an indigenous plant used in Ayurvedic medicine in India. Administration of the extract of T. cordifolia roots (2.5 and 5.0 g/kg body weight) for 6 weeks resulted in a significant reduction in serum and tissue cholesterol, phospholipids and free fatty acids in alloxan diabetic rats. The root extract at a dose of 5.0 g/kg body weight showed highest hypolipidaemic effect. The effect of T. cordifolia roots at 2.5 and 5.0 g/kg body weight was better than glibenclamide.

Author(s): 
Stanely Mainzen Prince, P.
Menon, V. P.
Gunasekaran, G.
Publication Title: 
Journal of Ethnopharmacology

We made an attempt to study the antioxidant properties of Tinospora cordifolia roots, an indigenous plant used in Ayurvedic medicine in India in alloxan diabetic rats. Oral administration of an aqueous T. cordifolia root extract (TCREt) (2.5 and 5.0 g/kg) for 6 weeks resulted in a decrease in the levels of plasma thiobarbituric acid reactive substances, ceruloplasmin and alpha-tocopherol in alloxan diabetic rats. The root extract also causes an increase in the levels of glutathione and vitamin C in alloxan diabetes. The root extract at a dose of 5.0 g/kg showed the highest effect.

Author(s): 
Prince, P. S.
Menon, V. P.
Publication Title: 
Phytotherapy research: PTR

Tinospora cordifolia is widely used in Indian Ayurvedic medicine for the treatment of diabetes mellitus. Oral administration of 2.5 g and 5.0 g/kg body weight of the aqueous extract of the roots for 6 weeks resulted in a significant reduction in thiobarbituric acid reactive substances (TBARS) and an increase in reduced glutathione (GSH), catalase (CAT) and superoxide dismutase (SOD) in alloxan diabetic rats. The effect of Tinospora cordifolia root extract (TCREt) was most prominently seen in the case of rats given 5.0 g/kg body weight.

Author(s): 
Stanely Mainzen Prince, P.
Menon, V. P.
Publication Title: 
Pharmacological Research: The Official Journal of the Italian Pharmacological Society

Hyperlipidemia is an associated complication of diabetes mellitus. Many spices and herbs are known to be hypoglycaemic. Cuminum cyminum belonging to the family Apiaceae is widely used in Ayurvedic medicine for the treatment of dyspepsia, diarrhoea and jaundice. The present work was done to study the role of C. cyminum supplementation on the plasma and tissue lipids in alloxan diabetic rats. Oral administration of 0.25 g kg(-1) body weight of C.

Author(s): 
Dhandapani, Surya
Subramanian, Vijayakumar Ramasamy
Rajagopal, Senthilkumar
Namasivayam, Nalini
Publication Title: 
Phytotherapy research: PTR

The efficacy of Momordica charantia (MC), Eugenia jambolana (EJ), Tinospora cordifolia (TC) and Mucuna pruriens (MP) was assessed in the prevention of murine alloxan dibetic cataract. Alloxan (120 mg/kg) was used as the diabetogenic agent. While controls and diabetic controls did not receive any plant extract, treated rats received lyophilized aqueous extract of MC and EJ (200 mg/kg p.o.), alcohol extract of TC (400 mg/kg) and MP (200 mg/kg p.o.) every day until 4 months. Serum glucose concentration was assessed and cataracts examined with both the naked eye and through a slit lamp.

Author(s): 
Rathi, S. S.
Grover, J. K.
Vikrant, Vats
Biswas, N. R.
Publication Title: 
Phytotherapy research: PTR

The present investigation was undertaken to evaluate the hypoglycaemic and hypolipidaemic effects of an alcohol extract of Tinospora cordifolia roots, an indigenous plant used in Ayurvedic medicine in India. Oral administration of the extract of Tinospora cordifolia (TCREt) roots for 6 weeks resulted in a significant reduction in blood and urine glucose and in lipids in serum and tissues in alloxan diabetic rats. The extract also prevented a decrease in body weight. Thus our study clearly shows that an alcohol TCREt has a hypoglycaemic and hypolipidaemic action.

Author(s): 
Stanely Mainzen Prince, P.
Menon, Venugopal P.
Publication Title: 
Journal of Ethnopharmacology

Momordica charantia (L.) (Cucurbitaceae) commonly known as bitter gourd or karela is a medicinal plant, used in Ayurveda for treating various diseases, one of which is diabetes mellitus. In this study, various extract powders of the fresh and dried whole fruits were prepared and their blood glucose lowering effect compared by administrating them orally to diabetic rats. The aqueous extract powder of fresh unripe whole fruits at a dose of 20mg/kg body weight was found to reduce fasting blood glucose by 48%, an effect comparable to that of glibenclamide, a known synthetic drug.

Author(s): 
Virdi, Jaspreet
Sivakami, S.
Shahani, S.
Suthar, A. C.
Banavalikar, M. M.
Biyani, M. K.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: The leaf juice or water decoction of Catharanthus roseus L. (Apocyanaceae) is used as a folk medicine for the treatment of diabetes all over the world. In the present investigation, the leaf juice of C. roseus has been evaluated for its hypoglycemic activity in normal and alloxan-induced diabetic rabbits. METHODS: The blood glucose lowering activity of the leaf juice was studied in normal and alloxan-induced (100 mg/kg, i.v.) diabetic rabbits, after oral administration at doses of 0.5, 0.75 and 1.0 ml/kg body weight.

Author(s): 
Nammi, Srinivas
Boini, Murthy K.
Lodagala, Srinivas D.
Behara, Ravindra Babu S.
Publication Title: 
Indian Journal of Physiology and Pharmacology

Free radicals and associated oxidative stress induced by alloxan are implicated in eliciting pathological changes in diabetes mellitus. Terminalia arjuna bark, an indigenous plant used in ayurvedic medicine in India, primarily as a cardiotonic is also used in treating diabetes, anemia, tumors and hypertension. The present study examined the effect of ethanolic extract (250 and 500 mg/kg body weight) of Terminalia arjuna stem bark in alloxan induced diabetic rats and its lipid peroxidation, enzymatic and nonenzymatic activity was investigated in the liver and kidney tissues.

Author(s): 
Raghavan, B.
Kumari, S. Krishna

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