alpha-Amylases

Publication Title: 
Journal of Ethnopharmacology

The antiamoebic effect of a crude drug formulation against Entamoeba histolytica was studied. In the traditional system of medicine in India, the formulation has been prescribed for intestinal disorders. It comprises of five medicinal herbs, namely, Boerhavia diffusa, Berberis aristata, Tinospora cordifolia, Terminalia chebula and Zingiber officinale. The dried and pulverized plants were extracted in ethanol together and individually.

Author(s): 
Sohni, Y. R.
Kaimal, P.
Bhatt, R. M.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Indian medicinal plants used in the Ayurvedic traditional system to treat diabetes are a valuable source of novel anti-diabetic agents. Pancreatic ?-amylase inhibitors offer an effective strategy to lower the levels of post-prandial hyperglycemia via control of starch breakdown. In this study, seventeen Indian medicinal plants with known hypoglycemic properties were subjected to sequential solvent extraction and tested for ?-amylase inhibition, in order to assess and evaluate their inhibitory potential on PPA (porcine pancreatic ?-amylase).

Author(s): 
P, Sudha
Zinjarde, Smita S.
Bhargava, Shobha Y.
Kumar, Ameeta R.
Publication Title: 
Bioorganic & Medicinal Chemistry Letters

Three new polyhydroxytriterpenoid derivatives, 23-O-neochebuloylarjungenin 28-O-?-d-glycopyranosyl ester (1), 23-O-4'-epi-neochebuloylarjungenin (2), and 23-O-galloylpinfaenoic acid 28-O-?-d-glucopyranosyl ester (17) were isolated from the fruits of Terminalia chebula Retz. along with fourteen known ones. Their structures were elucidated by 1D and 2D NMR spectroscopic data and acid hydrolysis.

Author(s): 
Lee, Dong Young
Yang, Heejung
Kim, Hyun Woo
Sung, Sang Hyun
Publication Title: 
Psychiatry Research

Free radicals/reactive oxygen species are related to many biological phenomena such as inflammation, aging, and carcinogenesis. The body possesses various antioxidative systems (free radical scavenging activity, FRSA) for preventing oxidative stress, and saliva contains such activity. In the present study, we measured the total salivary FRSA induced after the smelling of lavender and rosemary essential oils that are widely used in aromatherapy.

Author(s): 
Atsumi, Toshiko
Tonosaki, Keiichi
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Indian medicinal plants used in the Ayurvedic traditional system to treat diabetes are a valuable source of novel anti-diabetic agents. Pancreatic α-amylase inhibitors offer an effective strategy to lower the levels of post-prandial hyperglycemia via control of starch breakdown. In this study, seventeen Indian medicinal plants with known hypoglycemic properties were subjected to sequential solvent extraction and tested for α-amylase inhibition, in order to assess and evaluate their inhibitory potential on PPA (porcine pancreatic α-amylase).

Author(s): 
P, Sudha
Zinjarde, Smita S.
Bhargava, Shobha Y.
Kumar, Ameeta R.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Traditional Indian and Australian medicinal plant extracts were investigated to determine their therapeutic potential to inhibit key enzymes in carbohydrate metabolism, which has relevance to the management of hyperglycemia and type 2 diabetes. The antioxidant activities were also assessed. METHODS: The evaluation of enzyme inhibitory activity of seven Australian aboriginal medicinal plants and five Indian Ayurvedic plants was carried out against α-amylase and α-glucosidase.

Author(s): 
Gulati, Vandana
Harding, Ian H.
Palombo, Enzo A.
Publication Title: 
Biological & Pharmaceutical Bulletin

In India, Azadirachta indica is typically known as 'neem tree' and its leaves has long been used in the ayurvedic medical tradition as a treatment for diabetes mellitus. In-depth chromatographic investigation on chloroform extract resulted in identification of one new tetranortriterpenoid. Structural elucidation was established on the basis of spectral data as 24,25,26,27-tetranor-apotirucalla-(apoeupha)-1α-senecioyloxy-3α,7α-dihydroxy-14,20,22-trien-21,23-epoxy named by us as meliacinolin (1).

Author(s): 
Perez-Gutierrez, Rosa Martha
Damian-Guzman, Monica
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Indian medicinal plants used in the Ayurvedic traditional system to treat diabetes are a valuable source of novel anti-diabetic agents. Pancreatic α-amylase inhibitors offer an effective strategy to lower the levels of post-prandial hyperglycemia via control of starch breakdown. In this study, seventeen Indian medicinal plants with known hypoglycemic properties were subjected to sequential solvent extraction and tested for α-amylase inhibition, in order to assess and evaluate their inhibitory potential on PPA (porcine pancreatic α-amylase).

Author(s): 
P, Sudha
Zinjarde, Smita S.
Bhargava, Shobha Y.
Kumar, Ameeta R.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Traditional Indian and Australian medicinal plant extracts were investigated to determine their therapeutic potential to inhibit key enzymes in carbohydrate metabolism, which has relevance to the management of hyperglycemia and type 2 diabetes. The antioxidant activities were also assessed. METHODS: The evaluation of enzyme inhibitory activity of seven Australian aboriginal medicinal plants and five Indian Ayurvedic plants was carried out against α-amylase and α-glucosidase.

Author(s): 
Gulati, Vandana
Harding, Ian H.
Palombo, Enzo A.
Publication Title: 
Biological & Pharmaceutical Bulletin

In India, Azadirachta indica is typically known as 'neem tree' and its leaves has long been used in the ayurvedic medical tradition as a treatment for diabetes mellitus. In-depth chromatographic investigation on chloroform extract resulted in identification of one new tetranortriterpenoid. Structural elucidation was established on the basis of spectral data as 24,25,26,27-tetranor-apotirucalla-(apoeupha)-1α-senecioyloxy-3α,7α-dihydroxy-14,20,22-trien-21,23-epoxy named by us as meliacinolin (1).

Author(s): 
Perez-Gutierrez, Rosa Martha
Damian-Guzman, Monica

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