Amidines

Publication Title: 
International Journal of Radiation Biology
Author(s): 
Dacquisto, M. P.
Rothe, W. E.
Blackburn, E. W.
Publication Title: 
Toxicology Letters

The effect of chlordimeform (CDM) treatment on the hepatic microsomal drug metabolizing enzymes was examined in male and female rats following either acute or repeated treatment.

Author(s): 
Budris, D. M.
Yim, G. K.
Carlson, G. P.
Schnell, R. C.
Publication Title: 
Journal of Environmental Pathology, Toxicology and Oncology: Official Organ of the International Society for Environmental Toxicology and Cancer

The effect of chlordimeform treatment on the hepatic microsomal drug metabolizing enzymes was examined in male and female rats following either acute or repeated treatment.

Author(s): 
Budris, D. M.
Yim, G. K.
Schnell, R. C.
Publication Title: 
Brain Research Bulletin

Tonic immobility (TI), also known as death feigning or animal hypnosis, is a reversible state of motor inhibition that is triggered by postural inversion and/or movement restraining maneuvers but also by repetitive stimulation and pressure on body parts. Our previous studies demonstrated that cholinergic stimulation of the central amygdala (CEA) decreases the duration of TI in guinea pigs. Some reports have demonstrated that electrical or chemical stimulation of the CEA promotes antinociception.

Author(s): 
Leite-Panissi, Christie Ramos Andrade
Coimbra, Norberto Cysne
Menescal-de-Oliveira, Leda
Publication Title: 
Journal of Medicinal Chemistry

Novel dicationic triazoles 1-60 were synthesized by the Pinner method from the corresponding dinitriles, prepared via the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC). The type and the placement of cationic moieties as well as the nature of aromatic substituents influenced in vitro antiprotozoal activities of compounds 1-60 against Trypanosoma brucei rhodesiense, Plasmodium falciparum, and Leishmania donovani and their cytotoxicity for mammalian cells. Eight congeners displayed antitrypanosomal IC(50) values below 10 nM. Thirty-nine dications were more potent against P.

Author(s): 
Bakunov, Stanislav A.
Bakunova, Svetlana M.
Wenzler, Tanja
Ghebru, Maedot
Werbovetz, Karl A.
Brun, Reto
Tidwell, Richard R.
Publication Title: 
Romanian Journal of Internal Medicine = Revue Roumaine De Médecine Interne

The influence of Geriforte, an Ayurvedic natural supplement, on the antioxidant defense systems in human erythrocytes and plasma was investigated in an open human clinical study. The ability of Geriforte to inhibit the azo-bis 2-amidinopropane dihydrochloride (AAPH) dependent lysis of erythrocytes was also evaluated. Geriforte supplementation increased the activity of erythrocyte catalase (265.745 +/- 15.768 vs.

Author(s): 
Gilca, Marilena
Stoian, Irina
Lixandru, Daniela
Gaman, Laura
Vîrgolici, Bogdana
Atanasiu, V.
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