Amino Acid Chloromethyl Ketones

Publication Title: 
Journal of Biomedical Science

BACKGROUND: Dihydroartemisinin (DHA), a semi-synthetic derivative of artemisinin, isolated from the traditional Chinese herb Artemisia annua, is recommended as the first-line anti-malarial drug with low toxicity. DHA has been shown to possess promising anticancer activities and induce cancer cell death through apoptotic pathways, although the molecular mechanisms are not well understood. METHODS: In this study, cell counting kit (CCK-8) assay was employed to evaluate the survival of DHA-treated ASTC-a-1 cells.

Author(s): 
Lu, Ying-Ying
Chen, Tong-Sheng
Qu, Jun-Le
Pan, Wen-Liang
Sun, Lei
Wei, Xun-Bin
Publication Title: 
Cancer Letters

Ginsenosides are the main bioactive components in American ginseng, a commonly used herb. In this study, we showed that the ginsenoside Rh2 exhibited significantly more potent cell death activity than the ginsenoside Rg3 in HCT116 and SW480 colorectal cancer cells. Cell death induced by Rh2 is mediated in part by the caspase-dependent apoptosis and in part by the caspase-independent paraptosis, a type of cell death that is characterized by the accumulation of cytoplasmic vacuoles.

Author(s): 
Li, Binghui
Zhao, Jiong
Wang, Chong-Zhi
Searle, Jennifer
He, Tong-Chuan
Yuan, Chun-Su
Du, Wei
Publication Title: 
Experimental Dermatology

Non-melanoma skin cancers (NMSCs), one of the most common neoplasms, cause serious morbidity and mortality. Therefore, identification of non-toxic phytochemicals for prevention/treatment of NMSCs is highly desirable. Fisetin (3,3',4',7-tetrahydroxyflavone), a dietary flavonoid, present in fruits and vegetables possesses anti-oxidant and antiproliferative properties. The aim of this study was to investigate the chemotherapeutic potential of fisetin in cultured human epidermoid carcinoma A431 cells.

Author(s): 
Pal, Harish C.
Sharma, Samriti
Elmets, Craig A.
Athar, Mohammad
Afaq, Farrukh
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