Analgesics

Publication Title: 
Arzneimittel-Forschung

Beraprost sodium (sodium (+/-)-(1R*,2R*,3aS*,8bS*)-2,3,3a,8b-tetrahydro-2- hydroxy-1-[(E)-(3S*)-3-hydroxy-4-methyl-1-octen-6-ynyl]-1H- cyclopenta[b]benzofuran-5-butyrate, TRK-100) is an orally active epoprostenol (prostaglandin I2, PGI2) analogue. Its effect on the central nervous system (CNS) was studied. 1. When orally administered in mice, beraprost sodium at 0.3 mg/kg caused a flush of skin, a suppression of spontaneous motility, and a fall of body temperature.

Author(s): 
Murata, T.
Sakaya, S.
Hoshino, T.
Umetsu, T.
Hirano, T.
Nishio, S.
Publication Title: 
Critical Care Clinics

Psychological strategies can facilitate management of acute pain. Methods of intervening that are reviewed include information provision, cognitive methods such as self-statements, distraction or attention control, relaxation, and hypnosis. Individual patient coping style and anxiety may moderate need for or ability to use these techniques. Increasing perceived control may be an underlying factor common to all psychological interventions for the management of pain.

Author(s): 
VanDalfsen, P. J.
Syrjala, K. L.
Publication Title: 
The Journal of Rheumatology

In a controlled study, 40 patients with refractory fibromyalgia were randomly allocated to treatment with either hypnotherapy or physical therapy for 12 weeks with followup at 24 weeks. Compared with the patients in the physical therapy group, the patients in the hypnotherapy group showed a significantly better outcome with respect to their pain experience, fatigue on awakening, sleep pattern and global assessment at 12 and 24 weeks, but this was not reflected in an improvement of the total myalgic score measured by a dolorimeter.

Author(s): 
Haanen, H. C.
Hoenderdos, H. T.
van Romunde, L. K.
Hop, W. C.
Mallee, C.
Terwiel, J. P.
Hekster, G. B.
Publication Title: 
Neuropharmacology

The effect of the GABAA antagonists, bicuculline and picrotoxin, in the hot plate and writhing tests in mice and the paw-pressure test in rats was assessed. Subconvulsant doses of bicuculline (1.3-4 mumol kg-1, s.c.) or picrotoxin (0.8-2.5 mumol kg-1, s.c.) induced a dose-related increase in latency of licking in the hot plate test in mice, whereas subconvulsant doses of strychnine and thiosemicarbazide (0.9 and 6 mg kg-1, s.c. respectively), did not modify the threshold to thermal stimuli in mice.

Author(s): 
Malcangio, M.
Malmberg-Aiello, P.
Giotti, A.
Ghelardini, C.
Bartolini, A.
Publication Title: 
Indian Journal of Experimental Biology

1-(2-benzothiazolyl)-1-aryl-3-phenyl-4-arylguanidines (I-X) were prepared by oxidation of 1,3-diarylthioureas. The compounds were screened for their analgesic and hypnotic activities in rats. Of these, p-methyl group substituted compound of the series was the most potent analgesic as compared to other compounds of the series. In hypnotic test all the compounds potentiated pentobarbitone-induced hypnosis.

Author(s): 
Siddiqui, N.
Pandeya, S. N.
Publication Title: 
British Journal of Obstetrics and Gynaecology

OBJECTIVE: To assess the effects of hypnotherapy on the first and second stages of labour in a large group of pregnant women. DESIGN: A semi-prospective case control study in which women attending antenatal clinics were invited to undergo hypnotherapy. SUBJECTS: One hundred twenty-six primigravid women with 300 age matched controls, and 136 parous women having their second baby with 300 age matched controls. Only women who had spontaneous deliveries were included. SETTING: Aberdare District Maternity Unit, Mid Glamorgan, Wales.

Author(s): 
Jenkins, M. W.
Pritchard, M. H.
Publication Title: 
Planta Medica

We report the effects on the central nervous system (CNS) and on analgesic activity of a fraction (F2) obtained from a Himanthalia elongata extract. The fraction was assayed for effects on spontaneous locomotor activity, d-amphetamine-induced hypermotility, motor coordination, muscular relaxation, rectal temperature, sodium pentobarbital-induced hypnosis, and pentylenetetrazole-induced convulsions. Analgesic activity was evaluated using the hot plate test and the Randall-Selitto test (1).

Author(s): 
Anca, J. M.
Lamela, M.
Gato, M. A.
Cadavid, I.
Calleja, J. M.
Publication Title: 
Planta Medica

We report the effects of a fraction (F1) obtained from Himanthalia elongata on spontaneous locomotor activity, hypermotility, motor coordination, rectal temperature, pentobarbitone-induced hypnosis, pentylenetetrazole-induced convulsions and analgesic activity in the writhing and hot-plate tests. This fraction caused very significant reductions in spontaneous locomotor activity, hypermotility, and rectal temperature. It postponed pentylenetetrazole-induced death and a slight increase of sleeping time was noted in the sodium pentobarbital-induced sleep test .

Author(s): 
Anca, J. M.
Lamela, M.
Calleja, J. M.
Publication Title: 
Pain

The aims of this study were to (a) investigate the efficacy of autogenic training (AT) and cognitive self-hypnosis training (CSH) for the treatment of chronic headaches in comparison with a waiting-list control (WLC) condition, (b) investigate the influence of subject recruitment on treatment outcome and (c) explore whether the level of hypnotizability is related to therapy outcome.

Author(s): 
ter Kuile, M. M.
Spinhoven, P.
Linssen, A. C.
Zitman, F. G.
Van Dyck, R.
Rooijmans, H. G.
Publication Title: 
Chemical & Pharmaceutical Bulletin

The methanol extract of Huira-Huira (Culcitium canescens) showed analgesic effects in acetic acid-induced writhing and tail pressure tests, and it also produced potent prolongation of hypnosis induced by pentobarbital. The latter activity was used as an isolation-guide to determine the active components which were identified as dehydrocacalohastine, cacalohastine and cacalonol.

Author(s): 
Okuyama, E.
Umeyama, K.
Ohmori, S.
Yamazaki, M.
Satake, M.

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