Androgens

Publication Title: 
Current Opinion in Endocrinology, Diabetes, and Obesity

PURPOSE OF REVIEW: Despite an incidence of 1% among women under the age of 40, primary ovarian insufficiency (POI) is still poorly understood. As the variable cause and presentation of POI complicate its management, a standard regimen for treatment remains to be established. However, emerging research has provided new insight on current mainstays of treatment as well as novel management approaches and therapeutic interventions.

Author(s): 
Hewlett, Meghan
Mahalingaiah, Shruthi
Publication Title: 
Best Practice & Research. Clinical Endocrinology & Metabolism

Sex differences in lifespan exist world-wide, with women outliving men by more than a decade in some countries. The gender gap is not a uniquely human phenomenon; most sexually reproducing species examined show sex differences in patterns of ageing, yet a comprehensive explanation does not exist. Here, we discuss how ageing responds to natural selection on traits that arise as a consequence of sexuality.

Author(s): 
Regan, Jennifer C.
Partridge, Linda
Publication Title: 
Free Radical Biology & Medicine

Steroid hormones exhibit diverse biological activities. Despite intensive studies on steroid function at the genomic level, their nongenomic actions remain an enigma. In this study, we investigated the role of reactive oxygen species (ROS) in androgen-stimulated prostate cancer (PCa) cell proliferation. In androgen-treated PCa cells, increased cell growth and ROS production correlated with elevated p66Shc protein, an authentic oxidase. This growth stimulation was blocked by antioxidants.

Author(s): 
Veeramani, Suresh
Chou, Yu-Wei
Lin, Frank C.
Muniyan, Sakthivel
Lin, Fen-Fen
Kumar, Satyendra
Xie, Yan
Lele, Subodh M.
Tu, Yaping
Lin, Ming-Fong
Publication Title: 
Best Practice & Research. Clinical Endocrinology & Metabolism

Sex differences in lifespan exist world-wide, with women outliving men by more than a decade in some countries. The gender gap is not a uniquely human phenomenon; most sexually reproducing species examined show sex differences in patterns of ageing, yet a comprehensive explanation does not exist. Here, we discuss how ageing responds to natural selection on traits that arise as a consequence of sexuality.

Author(s): 
Regan, Jennifer C.
Partridge, Linda
Publication Title: 
Experimental Gerontology
Author(s): 
Everitt, A. V.
Publication Title: 
Physiology & Behavior

Adult voles show sexual differences in their behavioral responses to estrogen. To determine whether this sexual dimorphism is related to early androgen exposure as it is in other rodents, female voles were treated neonatally with testosterone. In addition, males were castrated neonatally or treated perinatally with either the antiandrogen, flutamide or with the antiaromatase, ATD. When androgenized females were treated with estrogen in adulthood, they exhibited normal sexual behaviors.

Author(s): 
Petersen, S. L.
Publication Title: 
Phytotherapy research: PTR

Anacyclus pyrethrum (A. pyrethrum) has been used as Vajikaran Rasayana (aphrodisiac) in traditional Indian ayurvedic medicine to treat male sexual dysfunction, including infertility. Aphrodisiac activity may be due to an increase in the production or effect of androgens, so this study sought to evaluate the androgenic and spermatogenic potential of the alkylamide-rich ethanol solution extract. Male Wistar strain rats weighing between 150 and 180 g were completely randomized divided into five groups. The ethanol solution extract of A.

Author(s): 
Sharma, Vikas
Boonen, Jente
Spiegeleer, Bart De
Dixit, V. K.
Publication Title: 
Hong Kong Medical Journal = Xianggang Yi Xue Za Zhi / Hong Kong Academy of Medicine

Unorthodox (non-traditional or alternative) medicinal practices have been expanding very rapidly in western countries. Modern physicians, scientists, and non-traditional medicine practitioners now must join forces to promote evidence-based medicine to benefit patients. Green tea extracts are among the most widely used ancient medicinal agents, while androgens are probably the oldest drugs used in a purified form in traditional Chinese medicine.

Author(s): 
Liao, S.
Publication Title: 
Cancer Research

An isocaloric low-fat diet has been shown to slow androgen-sensitive Los Angeles Prostate Cancer-4 (LAPC-4) tumor growth in a mouse xenograft model. LAPC-4 cells were injected into male severe combined immunodeficient mice. After palpable tumors developed, the mice were divided into three groups, high-fat intact, high-fat castration, and low-fat castration. Tumor latency (18 versus 9 weeks; P < 0.001) and mouse survival (20.8 +/- 1.3 versus 13 +/- 0.7 weeks; P < 0.01) were significantly longer in the low-fat castration versus high-fat castration group.

Author(s): 
Ngo, Tung H.
Barnard, R. James
Anton, Todd
Tran, Chris
Elashoff, David
Heber, David
Freedland, Stephen J.
Aronson, William J.
Publication Title: 
Cancer Research

Alteration of lipid metabolism is commonly observed in sex hormone-dependent cancer cells, yet its mechanistic involvement in cancer cell proliferation and progression is unclear. We have found that the expression of the cholesterol transporter, ATP-binding cassette transporter A1 (ABCA1), was 15- to 20-fold higher in androgen-dependent than in androgen-independent LNCaP human prostate cancer cells, indicating a possible relationship between the expression levels of ABCA1 and prostate cancer progression.

Author(s): 
Fukuchi, Junichi
Hiipakka, Richard A.
Kokontis, John M.
Hsu, Stephen
Ko, Andrew L.
Fitzgerald, Michael L.
Liao, Shutsung

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