Anesthetics, Intravenous

Publication Title: 
CNS drugs

BACKGROUND: The aim of this study was to evaluate the usefulness of spectral frequency index (SFx) monitoring to assess the depth of anaesthesia during propofol-opioid total intravenous anaesthesia (TIVA). METHODS: Thirty-three patients scheduled for laparoscopic cholecystectomy under propofol TIVA were prospectively and randomly allocated to receive either remifentanil (bolus of 1.0 microg/kg, followed by continuous infusion from 0.25 to 0.05 microg/kg/min) [n = 18] or alfentanil (bolus of 10 microg/kg, followed by continuous infusion from 2.0 to 0.5 microg/kg/min) [n = 15].

Author(s): 
Zaba, Zbigniew
Bienert, Agnieszka
Drobnik, Leon
Dyderski, Stanislaw
Kusza, Krzysztof
Publication Title: 
Acta Anaesthesiologica Scandinavica

BACKGROUND: In 2004, the cerebral state monitor, CSM, was launched as a low-cost alternative to the bispectral index, BIS, for monitoring depth of sleep during anaesthesia. We tested whether the two monitors would reflect hypnosis equally during propofol/remifentanil anaesthesia. METHODS: During laparoscopy or breast/surface surgery, 55 non-paralyzed patients were monitored simultaneously with the BIS and the CSM. Trend curves for the indexes [BIS and cerebral state index (CSI)] were compared for congruence.

Author(s): 
Hoymork, S. C.
Hval, K.
Jensen, E. W.
Raeder, J.
Publication Title: 
European Journal of Anaesthesiology

BACKGROUND AND OBJECTIVES: Electroencephalographic entropy is used to measure the degree of brain hypnosis and anaesthesia depth. Two parameters are displayed in the monitor, state entropy (SE) and response entropy (RE). Ageing leads to reduction in liver mass as well as hepatic blood flow, which decreases clearance of propofol and increases the risk of cardiovascular adverse effects. The aim of this study is to demonstrate the effect of electroencephalographic entropy on propofol requirement and haemodynamic parameters during induction of anaesthesia in elderly patients.

Author(s): 
Riad, W.
Schreiber, M.
Saeed, A. B.
Publication Title: 
Rhinology

OBJECTIVES: Controlled hypotension is used to improve surgical conditions during microscopic and endoscopic sinus surgery. Several drug combinations are suitable to provide deep and predictable level of anaesthesia combined with an exact control of intraoperative blood pressure. However, only little is known about the relative importance of the level of hypnosis on the one hand and analgesia on the other hand. STUDY DESIGN: Prospective, randomized, patient and observer-blinded study.

Author(s): 
Eberhart, L. H. J.
Kussin, A.
Arndt, C.
Lange, H.
Folz, B. J.
Werner, J. A.
Wulf, H.
Kill, C.
Publication Title: 
European Journal of Anaesthesiology

BACKGROUND AND OBJECTIVE: Midlatency auditory-evoked potentials, as measures of the anaesthetic state, were evaluated at similar levels of bispectral index in cardiac surgical patients maintained with either propofol or isoflurane anaesthesia. METHODS: Twenty-four patients were randomly allocated to anaesthesia with propofol (n = 12) or isoflurane (n = 12). Bispectral index was maintained below 60 during surgery.

Author(s): 
Musialowicz, T.
Niskanen, M.
Yppärilä-Wolters, H.
Pöyhönen, M.
Pitkänen, O.
Hynynen, M.
Publication Title: 
Anesthesiology

BACKGROUND: T-type calcium channels regulate neuronal membrane excitability and participate in a number of physiologic and pathologic processes in the central nervous system, including sleep and epileptic activity. Volatile anesthetics inhibit native and recombinant T-type calcium channels at concentrations comparable to those required to produce anesthesia. To determine whether T-type calcium channels are involved in the mechanisms of anesthetic action, the authors examined the effects of general anesthetics in mutant mice lacking alpha1G T-type calcium channels.

Author(s): 
Petrenko, Andrey B.
Tsujita, Mika
Kohno, Tatsuro
Sakimura, Kenji
Baba, Hiroshi
Publication Title: 
Anaesthesia and Intensive Care

Propofol anaesthesia using target control infusion during cardiac surgery has become more popular recently. However, without depth of anaesthesia monitoring, the standard target concentration used may be higher than necessary to maintain adequate hypnosis during hypothermic cardiopulmonary bypass. The purpose of this study was to evaluate the effect of bispectral index monitoring on propofol administration during hypothermic cardiopulmonary bypass.

Author(s): 
Chiu, C. L.
Ong, G.
Majid, A. A.
Publication Title: 
Acta Cirúrgica Brasileira / Sociedade Brasileira Para Desenvolvimento Pesquisa Em Cirurgia

PURPOSE: To compare, by continuous infusion of ketamine or medetomidine combined to methotrimeprazine and buprenorphine, ketamine and midazolam, the degree of hypnosis, myorelaxation, anesthetic quality and surgical feasibility through evaluation of possible parametric alterations and recovery quality. METHODS: 20 healthy adult females dogs, aged 3 to 5 years, body weight between 7 and 15 kg, were assigned randomly and homogenously to 2 groups of 10 animals each (n=10), group 1 (G1) and group 2 (G2), respectively.

Author(s): 
Silva, Fernando do Carmo
Hatschbach, Eduardo
Lima, Alfredo Feio da Maia
Carvalho, Yuri Karaccas de
Massone, Flávio
Publication Title: 
Saudi Medical Journal

OBJECTIVE: To compare their effects on cardiorespiratoy and recovery parameters and side effects. METHODS: This study was performed in The Ministry of Health Ankara Numune Research and Training Hospital, Ankara, Turkey, from January to May 2005. The 40 American Society of Anesthesiology II/III patients were randomized into 2 groups. All patients received remifentanil 0.75 microgram.kg(-1); and then received either etomidate 0.1 mg.kg(-1) (group E, n=20) or propofol 0.5 mg.kg(-1) (group P, n=20).

Author(s): 
Akcaboy, Zeynep N.
Akcaboy, Erkan Y.
Altinoren, Berrin
Karabulut, Erdem
Gogus, Nermin
Publication Title: 
Revista Española De Anestesiología Y Reanimación

OBJECTIVE: To determine possible variations in plasma levels of melatonin in patients sedated with propofol administered in continuous infusion. PATIENTS AND METHODS: Healthy patients receiving spinal anesthesia for lower limb orthopedic surgery were randomized to 2 groups in this prospective study: group A patients were sedated with intravenous propofol infused at a rate of 3 to 4 mg kg(-1) h(-1) and group B underwent surgery without sedation. Data from these groups were compared with data from 2 other groups.

Author(s): 
Castro, M. Ruiz
Pastor, A. Bardina
Alcantud, J. Fernández
Salván, J. Hernández
Osado, I. Riquelme
Roca, A. Planas

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